Ohkanda J - Search Results

1

Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.

Sun J, Blaskovich MA, Knowles D, Qian Y, Ohkanda J, Bailey RD, Hamilton AD, Sebti SM. Sun J, et al. Among authors: ohkanda j. Cancer Res. 1999 Oct 1;59(19):4919-26. Cancer Res. 1999. PMID: 10519405

2

Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization.

Kucich U, Rosenbloom JC, Shen G, Abrams WR, Blaskovich MA, Hamilton AD, Ohkanda J, Sebti SM, Rosenbloom J. Kucich U, et al. Among authors: ohkanda j. Biochem Biophys Res Commun. 1998 Nov 9;252(1):111-6. doi: 10.1006/bbrc.1998.9544. Biochem Biophys Res Commun. 1998. PMID: 9813154 Free article.

3

Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.

Vasudevan A, Qian Y, Vogt A, Blaskovich MA, Ohkanda J, Sebti SM, Hamilton AD. Vasudevan A, et al. Among authors: ohkanda j. J Med Chem. 1999 Apr 22;42(8):1333-40. doi: 10.1021/jm9900873. J Med Chem. 1999. PMID: 10212118

4

Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Lantry LE, Zhang Z, Yao R, Crist KA, Wang Y, Ohkanda J, Hamilton AD, Sebti SM, Lubet RA, You M. Lantry LE, et al. Among authors: ohkanda j. Carcinogenesis. 2000 Jan;21(1):113-6. doi: 10.1093/carcin/21.1.113. Carcinogenesis. 2000. PMID: 10607742

5

Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta.

Adnane J, Bizouarn FA, Chen Z, Ohkanda J, Hamilton AD, Munoz-Antonia T, Sebti SM. Adnane J, et al. Among authors: ohkanda j. Oncogene. 2000 Nov 16;19(48):5525-33. doi: 10.1038/sj.onc.1203920. Oncogene. 2000. PMID: 11114730

6

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.

Crespo NC, Ohkanda J, Yen TJ, Hamilton AD, Sebti SM. Crespo NC, et al. Among authors: ohkanda j. J Biol Chem. 2001 May 11;276(19):16161-7. doi: 10.1074/jbc.M006213200. Epub 2001 Jan 11. J Biol Chem. 2001. PMID: 11154688 Free article.

7

Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.

Ohkanda J, Lockman JW, Yokoyama K, Gelb MH, Croft SL, Kendrick H, Harrell MI, Feagin JE, Blaskovich MA, Sebti SM, Hamilton AD. Ohkanda J, et al. Bioorg Med Chem Lett. 2001 Mar 26;11(6):761-4. doi: 10.1016/s0960-894x(01)00055-5. Bioorg Med Chem Lett. 2001. PMID: 11277514

8

Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.

Ohkanda J, Lockman JW, Kothare MA, Qian Y, Blaskovich MA, Sebti SM, Hamilton AD. Ohkanda J, et al. J Med Chem. 2002 Jan 3;45(1):177-88. doi: 10.1021/jm0103099. J Med Chem. 2002. PMID: 11754590

9

Inhibitors of protein farnesyltransferase as novel anticancer agents.

Ohkanda J, Knowles DB, Blaskovich MA, Sebti SM, Hamilton AD. Ohkanda J, et al. Curr Top Med Chem. 2002 Mar;2(3):303-23. doi: 10.2174/1568026023394281. Curr Top Med Chem. 2002. PMID: 11944822 Review.

10

The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.

Crespo NC, Delarue F, Ohkanda J, Carrico D, Hamilton AD, Sebti SM. Crespo NC, et al. Among authors: ohkanda j. Cell Death Differ. 2002 Jul;9(7):702-9. doi: 10.1038/sj.cdd.4401023. Cell Death Differ. 2002. PMID: 12058275

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