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Page 1
Genetic modifiers of APOE-ε4-associated cognitive decline.
Contreras AG, Walters S, Eissman JM, Archer DB, Regelson AN, Durant A, Clifton M, Mukherjee S, Lee ML, Choi SE, Scollard P, Trittschuh EH, Mez J, Bush WS, Kunkle BW, Cruchaga C, Naj AC, Gifford KA, Bilgel M, Kuzma AB; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer’s Disease Genetics Consortium (ADGC); Alzheimer’s Disease Sequencing Project (ADSP); Cuccaro ML, Pericak-Vance MA, Farrer LA, Wang LS, Schellenberg GD, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Albert MS, Johnson SC, Engelman CD, Ferrucci L, Bennett DA, Barnes LL, Schneider JA, Sperling RA, Resnick SM, Crane PK, Dumitrescu L, Hohman TJ. Contreras AG, et al. Nat Commun. 2026 Feb 20. doi: 10.1038/s41467-026-68933-z. Online ahead of print. Nat Commun. 2026. PMID: 41720779 Free article.
Cortical asymmetry in autosomal dominant Alzheimer's disease progression.
Pérez-Millan A, Falgàs N, Bosch B, Borrego-Écija S, Antonell A, Fernández-Villullas G, Esteller-Gauxax D, Tort-Merino A, Bargalló N, Balasa M, Lladó A, Aguillon D, Chrem P, Day GS, Devenney E, Huey ED, Ikeuchi T, Jucker M, Kasuga K, Vöglein J, Roh JH, Vitali P, Sosa Ortiz AL, Llibre-Guerra JJ, Gordon BA, McDade E, Bateman RJ, Sánchez-Valle R; Dominantly Inherited Alzheimer Network (DIAN). Pérez-Millan A, et al. Brain Commun. 2025 Dec 19;8(1):fcaf488. doi: 10.1093/braincomms/fcaf488. eCollection 2026. Brain Commun. 2025. PMID: 41523185 Free PMC article.
Mapping the genetic landscape across 14 psychiatric disorders.
Grotzinger AD, Werme J, Peyrot WJ, Frei O, de Leeuw C, Bicks LK, Guo Q, Margolis MP, Coombes BJ, Batzler A, Pazdernik V, Biernacka JM, Andreassen OA, Anttila V, Børglum AD, Breen G, Cai N, Demontis D, Edenberg HJ, Faraone SV, Franke B, Gandal MJ, Gelernter J, Hatoum AS, Hettema JM, Johnson EC, Jonas KG, Knowles JA, Koenen KC, Maihofer AX, Mallard TT, Mattheisen M, Mitchell KS, Neale BM, Nievergelt CM, Nurnberger JI, O'Connell KS, Peterson RE, Robinson EB, Sanchez-Roige SS, Santangelo SL, Scharf JM, Stefansson H, Stefansson K, Stein MB, Strom NI, Thornton LM, Tucker-Drob EM, Verhulst B, Waldman ID, Walters GB, Wray NR, Yu D; Anxiety Disorders Working Group of the Psychiatric Genomics Consortium; Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group of the Psychiatric Genomics Consortium; Autism Spectrum Disorders Working Group of the Psychiatric Genomics Consortium; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium; Eating Disorders Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Nicotine Dependence GenOmics (iNDiGO) Consortium; Obsessive-Compulsive Disorder and Tourett… See abstract for full author list ➔ Grotzinger AD, et al. Nature. 2026 Jan;649(8096):406-415. doi: 10.1038/s41586-025-09820-3. Epub 2025 Dec 10. Nature. 2026. PMID: 41372416 Free PMC article.
Lymphoid gene expression supports neuroprotective microglia function.
Ayata P, Crowley JM, Challman MF, Sahasrabuddhe V, Gratuze M, Werneburg S, Ribeiro D, Hays EC, Durán-Laforet V, Faust TE, Hwang P, Mendes Lopes F, Nikopoulou C, Buchholz S, Murphy RE, Mei T, Pimenova AA, Romero-Molina C, Garretti F, Patel TA, De Sanctis C, Ramirez Jimenez AV, Crow M, Weiss FD, Ulrich JD, Marcora E, Murray JW, Meissner F, Beyer A, Hasson D, Crary JF, Schafer DP, Holtzman DM, Goate AM, Tarakhovsky A, Schaefer A. Ayata P, et al. Among authors: goate am. Nature. 2025 Dec;648(8092):157-165. doi: 10.1038/s41586-025-09662-z. Epub 2025 Nov 5. Nature. 2025. PMID: 41193812 Free PMC article.
Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder.
Green NC, Gao H, Chu X, Yuan Q, McGuire P, Lai D, Jiang G, Xuei X, Reiter JL, Stevens J, Sutherland GT, Goate AM, Pang ZP, Slesinger PA, Hart RP, Tischfield JA, Agrawal A, Wang Y, Duren Z, Edenberg HJ, Liu Y. Green NC, et al. Among authors: goate am. Nat Commun. 2025 Oct 13;16(1):9070. doi: 10.1038/s41467-025-64136-0. Nat Commun. 2025. PMID: 41083468 Free PMC article.
The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology.
McDade EM, Barthélemy NR, Wang G, Li Y, Cao Y, Gordon B, Benzinger TLS, Clifford D, Goate AM, Renton AE, Hassenstab J, Llibre-Guerra JJ, Perrin RJ, Xiong C, Cruchaga C, Mummery CJ, Berman SB, Lah J, Roberson ED, Van Dyck C, Gauthier S, Masters CL, Masellis M, Bittner T, Yaari R, Chhatwal J, Chrem P, Brooks W, Suzuki K, Levin JJ, Jucker M, Ringman J, Wallon D, Ikeuchi T, Lee JH, Roh JH, Schofield P, Fox NC, Ryan NS, Vöglein J, Karch C, Ibáñez L, Day GS, Sánchez-Valle R, Daniels A, Morris JC, Supnet-Bell C, Levey AI, Bateman RJ; DIAN‐TU Study Team and DIAN Obs Team. McDade EM, et al. Among authors: goate am. Alzheimers Dement. 2025 Sep;21(9):e70689. doi: 10.1002/alz.70689. Alzheimers Dement. 2025. PMID: 40985290 Free PMC article. Clinical Trial.
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.
Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, da Fonseca EL, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Ikeuchi T, Iqbal T, Pathak O, Valladares O, Reyes-Dumeyer D, Kuzma AB, Abner E, Adams LD, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Auerbach S, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Friedland RP, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, … See abstract for full author list ➔ Rajabli F, et al. Among authors: goate am. Genome Biol. 2025 Jul 17;26(1):210. doi: 10.1186/s13059-025-03564-z. Genome Biol. 2025. PMID: 40676597 Free PMC article.
373 results