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ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.
Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD. Westling J, et al. Among authors: hebert t. J Biol Chem. 2002 May 3;277(18):16059-66. doi: 10.1074/jbc.M108607200. Epub 2002 Feb 19. J Biol Chem. 2002. PMID: 11854269 Free article.
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Mosyak L, Georgiadis K, Shane T, Svenson K, Hebert T, McDonagh T, Mackie S, Olland S, Lin L, Zhong X, Kriz R, Reifenberg EL, Collins-Racie LA, Corcoran C, Freeman B, Zollner R, Marvell T, Vera M, Sum PE, Lavallie ER, Stahl M, Somers W. Mosyak L, et al. Among authors: hebert t. Protein Sci. 2008 Jan;17(1):16-21. doi: 10.1110/ps.073287008. Epub 2007 Nov 27. Protein Sci. 2008. PMID: 18042673 Free PMC article.
International expert consensus-driven surgical process model for robot-assisted hysterectomy: Delphi study results.
Nyangoh Timoh K, Galuret S, Hébert T, Azaïs H, Barahona M, Becker S, Bolze PA, Boisramé T, Borghese B, Carbonnel M, Cela V, Chauleur C, Chalhoub T, Cheung TH, Closon F, Crochet P, Dabi Y, De Landsheere L, Faller E, Fanfani F, Gauthier T, Gotlieb W, Ianieri MM, Ind T, Kim TJ, Koskas M, Ng J, Merlot B, Paek J, Philip CA, Raimondo D, Roman H, Rosendal M, Seracchioli R, Simoncini T, Tran PL, Tourette CM, Huaulmé A, Jannin P. Nyangoh Timoh K, et al. Among authors: hebert t. Surg Endosc. 2025 Oct 28. doi: 10.1007/s00464-025-12339-3. Online ahead of print. Surg Endosc. 2025. PMID: 41152527
Determinants of cervical high-risk human papillomavirus positivity among Rwandan women living with human immunodeficiency virus.
Murenzi G, Kanyabwisha F, Demarco M, Muhoza B, Hansen K, Mivumbi JP, Murangwa A, Rurangwa T, Zawadi TM, Kubwimana G, Gage JC, Hébert T, Adedimeji A, Nyirazinyoye L, Yotebieng M, Mutesa L, Anastos K, Castle PE. Murenzi G, et al. Among authors: hebert t. PLoS One. 2025 Sep 24;20(9):e0333077. doi: 10.1371/journal.pone.0333077. eCollection 2025. PLoS One. 2025. PMID: 40991629 Free PMC article.
311 results