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MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.
Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CC, Shlomchik MJ, Zamvil SS. Molnarfi N, et al. Among authors: slavin aj. J Exp Med. 2013 Dec 16;210(13):2921-37. doi: 10.1084/jem.20130699. Epub 2013 Dec 9. J Exp Med. 2013. PMID: 24323356 Free PMC article.
Malignant glioma cells use MHC class II transactivator (CIITA) promoters III and IV to direct IFN-gamma-inducible CIITA expression and can function as nonprofessional antigen presenting cells in endocytic processing and CD4(+) T-cell activation.
Soos JM, Krieger JI, Stüve O, King CL, Patarroyo JC, Aldape K, Wosik K, Slavin AJ, Nelson PA, Antel JP, Zamvil SS. Soos JM, et al. Among authors: slavin aj. Glia. 2001 Dec;36(3):391-405. doi: 10.1002/glia.1125. Glia. 2001. PMID: 11746775
MOG transmembrane and cytoplasmic domains contain highly stimulatory T-cell epitopes in MS.
Varrin-Doyer M, Shetty A, Spencer CM, Schulze-Topphoff U, Weber MS, Bernard CC, Forsthuber T, Cree BA, Slavin AJ, Zamvil SS. Varrin-Doyer M, et al. Among authors: slavin aj. Neurol Neuroimmunol Neuroinflamm. 2014 Aug 14;1(2):e20. doi: 10.1212/NXI.0000000000000020. eCollection 2014 Aug. Neurol Neuroimmunol Neuroinflamm. 2014. PMID: 25340072 Free PMC article.
43 results