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Page 1
P3 cap modified Phe*-Ala series BACE inhibitors.
Chen SH, Lamar J, Guo D, Kohn T, Yang HC, McGee J, Timm D, Erickson J, Yip Y, May P, McCarthy J. Chen SH, et al. Among authors: mccarthy j. Bioorg Med Chem Lett. 2004 Jan 5;14(1):245-50. doi: 10.1016/j.bmcl.2003.09.085. Bioorg Med Chem Lett. 2004. PMID: 14684336
Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR.
Lamar J, Hu J, Bueno AB, Yang HC, Guo D, Copp JD, McGee J, Gitter B, Timm D, May P, McCarthy J, Chen SH. Lamar J, et al. Among authors: mccarthy j. Bioorg Med Chem Lett. 2004 Jan 5;14(1):239-43. doi: 10.1016/j.bmcl.2003.09.084. Bioorg Med Chem Lett. 2004. PMID: 14684335
Design and synthesis of statine-containing BACE inhibitors.
Hu J, Cwi CL, Smiley DL, Timm D, Erickson JA, McGee JE, Yang HC, Mendel D, May PC, Shapiro M, McCarthy JR. Hu J, et al. Among authors: mccarthy jr. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4335-9. doi: 10.1016/j.bmcl.2003.09.037. Bioorg Med Chem Lett. 2003. PMID: 14643321
Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences.
Bueno AB, Agejas J, Broughton H, Dally R, Durham TB, Espinosa JF, González R, Hahn PJ, Marcos A, Rodríguez R, Sanz G, Soriano JF, Timm D, Vidal P, Yang HC, McCarthy JR. Bueno AB, et al. Among authors: mccarthy jr. J Med Chem. 2017 Dec 14;60(23):9807-9820. doi: 10.1021/acs.jmedchem.7b01304. Epub 2017 Nov 28. J Med Chem. 2017. PMID: 29088532
Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.
Yang HC, Chai X, Mosior M, Kohn W, Boggs LN, Erickson JA, McClure DB, Yeh WK, Zhang L, Gonzalez-DeWhitt P, Mayer JP, Martin JA, Hu J, Chen SH, Bueno AB, Little SP, McCarthy JR, May PC. Yang HC, et al. Among authors: mccarthy jr. J Neurochem. 2004 Dec;91(6):1249-59. doi: 10.1111/j.1471-4159.2004.02764.x. J Neurochem. 2004. PMID: 15584902
Conversion of human-selective PPARalpha agonists to human/mouse dual agonists: a molecular modeling analysis.
Wang M, Winneroski LL, Ardecky RJ, Babine RE, Brooks DA, Etgen GJ, Hutchison DR, Kauffman RF, Kunkel A, Mais DE, Montrose-Rafizadeh C, Ogilvie KM, Oldham BA, Peters MK, Rito CJ, Rungta DK, Tripp AE, Wilson SB, Xu Y, Zink RW, McCarthy JR. Wang M, et al. Among authors: mccarthy jr. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6113-6. doi: 10.1016/j.bmcl.2004.09.031. Bioorg Med Chem Lett. 2004. PMID: 15546740
3,545 results