Pascal JM - Search Results

1

Human DNA ligase I completely encircles and partially unwinds nicked DNA.

Pascal JM, O'Brien PJ, Tomkinson AE, Ellenberger T. Pascal JM, et al. Nature. 2004 Nov 25;432(7016):473-8. doi: 10.1038/nature03082. Nature. 2004. PMID: 15565146

2

DNA ligases: structure, reaction mechanism, and function.

Tomkinson AE, Vijayakumar S, Pascal JM, Ellenberger T. Tomkinson AE, et al. Among authors: pascal jm. Chem Rev. 2006 Feb;106(2):687-99. doi: 10.1021/cr040498d. Chem Rev. 2006. PMID: 16464020 Review. No abstract available.

3

Human DNA ligases I, III, and IV-purification and new specific assays for these enzymes.

Chen X, Pascal J, Vijayakumar S, Wilson GM, Ellenberger T, Tomkinson AE. Chen X, et al. Methods Enzymol. 2006;409:39-52. doi: 10.1016/S0076-6879(05)09003-8. Methods Enzymol. 2006. PMID: 16793394

4

A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.

Pascal JM, Tsodikov OV, Hura GL, Song W, Cotner EA, Classen S, Tomkinson AE, Tainer JA, Ellenberger T. Pascal JM, et al. Mol Cell. 2006 Oct 20;24(2):279-91. doi: 10.1016/j.molcel.2006.08.015. Mol Cell. 2006. PMID: 17052461 Free article.

5

RNA ligase does the AMP shuffle.

Pascal JM, Ellenberger T. Pascal JM, et al. Nat Struct Mol Biol. 2006 Nov;13(11):950-1. doi: 10.1038/nsmb1106-950. Nat Struct Mol Biol. 2006. PMID: 17082787 No abstract available.

6

The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1.

Song W, Pascal JM, Ellenberger T, Tomkinson AE. Song W, et al. Among authors: pascal jm. DNA Repair (Amst). 2009 Aug 6;8(8):912-9. doi: 10.1016/j.dnarep.2009.05.002. Epub 2009 Jun 11. DNA Repair (Amst). 2009. PMID: 19523882 Free PMC article.

7

The rise and fall of poly(ADP-ribose): An enzymatic perspective.

Pascal JM, Ellenberger T. Pascal JM, et al. DNA Repair (Amst). 2015 Aug;32:10-16. doi: 10.1016/j.dnarep.2015.04.008. Epub 2015 May 1. DNA Repair (Amst). 2015. PMID: 25963443 Free PMC article. Review.

8

Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation.

Matsumoto Y, Brooks RC, Sverzhinsky A, Pascal JM, Tomkinson AE. Matsumoto Y, et al. Among authors: pascal jm. J Mol Biol. 2020 Dec 4;432(24):166698. doi: 10.1016/j.jmb.2020.10.032. Epub 2020 Nov 4. J Mol Biol. 2020. PMID: 33157085 Free PMC article.

9

An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex.

Hammel M, Rashid I, Sverzhinsky A, Pourfarjam Y, Tsai MS, Ellenberger T, Pascal JM, Kim IK, Tainer JA, Tomkinson AE. Hammel M, et al. Among authors: pascal jm. Nucleic Acids Res. 2021 Jan 11;49(1):306-321. doi: 10.1093/nar/gkaa1188. Nucleic Acids Res. 2021. PMID: 33330937 Free PMC article.

10

Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus.

Rashid I, Hammel M, Sverzhinsky A, Tsai MS, Pascal JM, Tainer JA, Tomkinson AE. Rashid I, et al. Among authors: pascal jm. J Biol Chem. 2021 Aug;297(2):100921. doi: 10.1016/j.jbc.2021.100921. Epub 2021 Jun 25. J Biol Chem. 2021. PMID: 34181949 Free PMC article.

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