Hamilton AD - Search Results

1

Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells.

Zhu K, Gerbino E, Beaupre DM, Mackley PA, Muro-Cacho C, Beam C, Hamilton AD, Lichtenheld MG, Kerr WG, Dalton W, Alsina M, Sebti SM. Zhu K, et al. Among authors: hamilton ad. Blood. 2005 Jun 15;105(12):4759-66. doi: 10.1182/blood-2004-11-4307. Epub 2005 Feb 22. Blood. 2005. PMID: 15728126 Free PMC article.

2

Farnesyltransferase inhibitors as anticancer agents: current status.

Zhu K, Hamilton AD, Sebti SM. Zhu K, et al. Among authors: hamilton ad. Curr Opin Investig Drugs. 2003 Dec;4(12):1428-35. Curr Opin Investig Drugs. 2003. PMID: 14763128 Review.

3

Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues.

Sebti SM, Hamilton AD. Sebti SM, et al. Among authors: hamilton ad. Expert Opin Investig Drugs. 2000 Dec;9(12):2767-82. doi: 10.1517/13543784.9.12.2767. Expert Opin Investig Drugs. 2000. PMID: 11093352 Review.

4

The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells.

Bolick SC, Landowski TH, Boulware D, Oshiro MM, Ohkanda J, Hamilton AD, Sebti SM, Dalton WS. Bolick SC, et al. Among authors: hamilton ad. Leukemia. 2003 Feb;17(2):451-7. doi: 10.1038/sj.leu.2402832. Leukemia. 2003. PMID: 12592346

5

Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis.

Dan HC, Jiang K, Coppola D, Hamilton A, Nicosia SV, Sebti SM, Cheng JQ. Dan HC, et al. Oncogene. 2004 Jan 22;23(3):706-15. doi: 10.1038/sj.onc.1207171. Oncogene. 2004. PMID: 14737105

6

Protein farnesyltransferase: flexible docking studies on inhibitors using computational modeling.

Guida WC, Hamilton AD, Crotty JW, Sebti SM. Guida WC, et al. Among authors: hamilton ad. J Comput Aided Mol Des. 2005 Dec;19(12):871-85. doi: 10.1007/s10822-005-9030-2. Epub 2006 May 12. J Comput Aided Mol Des. 2005. PMID: 16607571

7

Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.

Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, Sebti SM. Falsetti SC, et al. Among authors: hamilton ad. Mol Cell Biol. 2007 Nov;27(22):8003-14. doi: 10.1128/MCB.00057-07. Epub 2007 Sep 17. Mol Cell Biol. 2007. PMID: 17875936 Free PMC article.

8

Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.

Balasis ME, Forinash KD, Chen YA, Fulp WJ, Coppola D, Hamilton AD, Cheng JQ, Sebti SM. Balasis ME, et al. Among authors: hamilton ad. Clin Cancer Res. 2011 May 1;17(9):2852-62. doi: 10.1158/1078-0432.CCR-10-2544. Clin Cancer Res. 2011. PMID: 21536547 Free PMC article.

9

Targeting protein prenylation for cancer therapy.

Berndt N, Hamilton AD, Sebti SM. Berndt N, et al. Among authors: hamilton ad. Nat Rev Cancer. 2011 Oct 24;11(11):775-91. doi: 10.1038/nrc3151. Nat Rev Cancer. 2011. PMID: 22020205 Free PMC article.

10

The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents.

Ohkanda J, Blaskovich MA, Sebti SM, Hamilton AD. Ohkanda J, et al. Among authors: hamilton ad. Prog Cell Cycle Res. 2003;5:211-7. Prog Cell Cycle Res. 2003. PMID: 14593715 Review.

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