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Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test.
Clark JA, Alves S, Gundlah C, Rocha B, Birzin ET, Cai SJ, Flick R, Hayes E, Ho K, Warrier S, Pai L, Yudkovitz J, Fleischer R, Colwell L, Li S, Wilkinson H, Schaeffer J, Wilkening R, Mattingly E, Hammond M, Rohrer SP. Clark JA, et al. Among authors: rohrer sp. Neuropharmacology. 2012 Nov;63(6):1051-63. doi: 10.1016/j.neuropharm.2012.07.004. Epub 2012 Jul 13. Neuropharmacology. 2012. PMID: 22796107
A beta-lactamase-dependent Gal4-estrogen receptor beta transactivation assay for the ultra-high throughput screening of estrogen receptor beta agonists in a 3456-well format.
Peekhaus NT, Ferrer M, Chang T, Kornienko O, Schneeweis JE, Smith TS, Hoffman I, Mitnaul LJ, Chin J, Fischer PA, Blizzard TA, Birzin ET, Chan W, Inglese J, Strulovici B, Rohrer SP, Schaeffer JM. Peekhaus NT, et al. Among authors: rohrer sp. Assay Drug Dev Technol. 2003 Dec;1(6):789-800. doi: 10.1089/154065803772613426. Assay Drug Dev Technol. 2003. PMID: 15090225
69 results