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PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes.
Seager BA, Lim PS, Xiao X, Lai KH, Feufack-Donfack LB, Dass S, Jung NC, Abraham A, Grigg MJ, Anstey NM, William T, Sattabongkot J, Leis A, Longley RJ, Duraisingh MT, Popovici J, Wilson DW, Cowman AF, Scally SW. Seager BA, et al. Among authors: cowman af. Nat Commun. 2026 Jan 26;17(1):1780. doi: 10.1038/s41467-026-68486-1. Nat Commun. 2026. PMID: 41587959 Free PMC article.
First-in-human safety and pharmacokinetics of MK-7602, the antimalarial inhibitor of plasmepsins IX/X, in single- and multiple-ascending-dose studies.
Stanley SE, Carstens RP, Liberti MV, Eertmans W, Vranckx M, Longo D, Ghosal N, Vavrek M, Olsen DB, Cowman AF, Reynders T, Cilissen C, Laethem T, Rottey S, Robbins JA, Stoch SA, Nussbaum J. Stanley SE, et al. Among authors: cowman af. Antimicrob Agents Chemother. 2026 Feb 4;70(2):e0126125. doi: 10.1128/aac.01261-25. Epub 2026 Jan 14. Antimicrob Agents Chemother. 2026. PMID: 41532789 Free PMC article. Clinical Trial.
Exploration and Characterization of the Antimalarial Activity of Pyrimidine-2,4-Diamines for which Resistance is Mediated by the ABCI3 Transporter.
Mansouri M, Dans MG, Low Z, Loi K, Jarman KE, Penington JS, Qiu D, Lehane AM, Crespo B, Gamo FJ, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE. Mansouri M, et al. Among authors: cowman af. ChemMedChem. 2026 Jan;21(1):e202500739. doi: 10.1002/cmdc.202500739. Epub 2025 Dec 12. ChemMedChem. 2026. PMID: 41387370 Free PMC article.
CD44 cross-linking promotes Plasmodium falciparum invasion.
Kongsomboonvech AK, Scally SW, Le Guen Y, Valissery P, Salinas ND, Cowman AF, Tolia NH, Egan ES. Kongsomboonvech AK, et al. Among authors: cowman af. Nat Commun. 2025 Dec 7;17(1):319. doi: 10.1038/s41467-025-67030-x. Nat Commun. 2025. PMID: 41354647 Free PMC article.
MK-7602: a potent multi-stage dual-targeting antimalarial.
Favuzza P, Palandri J, de Lera Ruiz M, Bailey W, Boyce CW, Danziger A, Fawaz MV, Kelly M, Murgolo N, Robbins JA, Vavrek M, Zhao L, Lei Z, Guo Z, Reaksudsan K, Steel RWJ, Hodder AN, Ngo A, Dziekan JM, Thompson JK, Triglia T, Birkinshaw RW, Penington JS, Scally SW, Dans MG, Coyle R, Sevilleno N, Orban A, Feufack-Donfack LB, Popovici J, Lee MCS, Papenfuss A, Lowes KN, Sleebs BE, McCarthy JS, McCauley JA, Boddey JA, Olsen DB, Cowman AF. Favuzza P, et al. Among authors: cowman af. EBioMedicine. 2026 Jan;123:106061. doi: 10.1016/j.ebiom.2025.106061. Epub 2025 Dec 6. EBioMedicine. 2026. PMID: 41353980 Free PMC article.
Deconvolution of the On-Target Activity of Plasmepsin V Peptidomimetics in Plasmodium falciparum Parasites.
Su W, Nguyen W, Siddiqui G, Dziekan JM, Marapana D, Penington JS, Mehra S, Razook Z, McCann K, Ngo A, Jarman KE, Barry AE, Papenfuss AT, Gilson PR, Creek DJ, Cowman AF, Sleebs BE, Dans MG. Su W, et al. Among authors: cowman af. ACS Infect Dis. 2025 Dec 12;11(12):3581-3594. doi: 10.1021/acsinfecdis.5c00742. Epub 2025 Dec 2. ACS Infect Dis. 2025. PMID: 41329554 Free PMC article.
359 results