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194 results

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POLB 001, a p38 MAPK inhibitor, decreases local and systemic inflammatory responses following in vivo LPS administration in healthy volunteers: a randomised, double-blind, placebo-controlled study.
de Bruin DT, Jansen MAA, Pereira DR, van Schijndel L, Klaassen ES, Otto ME, Skillington J, Maguire P, Tremble L, Bell A, Maher L, Mihara K, Sumeray M, Gilroy DW, Klarenbeek NB, Moerland M. de Bruin DT, et al. Among authors: gilroy dw. Front Immunol. 2026 Jan 23;16:1684307. doi: 10.3389/fimmu.2025.1684307. eCollection 2025. Front Immunol. 2026. PMID: 41660627 Free PMC article. Clinical Trial.
Challenges of monocyte HLA-DR targeted immunomodulation in sepsis-a prospective observational cohort study.
Snow TAC, Villa A, Cesar A, Ryckaert F, Saleem N, Smyth D, Pan H, Flint J, Brealey D, Singer M, Gilroy DW, Arulkumaran N; University College London Hospitals Critical Care Research Team. Snow TAC, et al. Among authors: gilroy dw. Front Immunol. 2026 Jan 7;16:1709289. doi: 10.3389/fimmu.2025.1709289. eCollection 2025. Front Immunol. 2026. PMID: 41573541 Free PMC article.
Epoxy-oxylipins direct monocyte fate in inflammatory resolution in humans.
Bracken OV, Jalali P, Glanville JRW, Benvenutti L, Chambers ES, Trahair H, Motwani M, Feehan KT, Evans JG, Carvalho JS, De Maeyer RPH, Akbar AN, Lih FB, Zeldin DC, Bishop-Bailey D, Edin ML, Gilroy DW. Bracken OV, et al. Among authors: gilroy dw. Nat Commun. 2026 Jan 16;17(1):431. doi: 10.1038/s41467-025-67961-5. Nat Commun. 2026. PMID: 41545341 Free PMC article.
Systematic review and meta-analysis of humoral immunity proteins and mortality in sepsis.
Villa A, Dewar F, Pisciotta W, Rai A, Kerneis S, Batum G, McDonnell T, Scully M, McHugh TD, Hilpert K, Gilroy D, de Nooijer A, Netea MG, Hedetoft M, Bermejo-Martin JF, Akatsuka M, Heinz CC, Venet F, Monneret G, Meessen J, Cheng TH, Zhang M, Caironi P, Giamarellos-Bourboulis EJ, de la Torre Terrón MC, Ebelt H, Rademaker E, Bodelsson M, Tverring J, Mi Y, Knight JC, Lindsey ML, Langley RJ, Kingsmore SF, Brealey D, Singer M, Arulkumaran N. Villa A, et al. Among authors: gilroy d. Crit Care. 2025 Dec 22;30(1):41. doi: 10.1186/s13054-025-05758-0. Crit Care. 2025. PMID: 41430733 Free PMC article.
Breaking Barriers: Characterization of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers.
van Ruissen MCE, van Diemen M, Botros L, Tomljanovic I, Achbo H, Eleftheriou D, Schenk PW, Klarenbeek NB, Gilroy DW, Jansen MAA, Moerland M. van Ruissen MCE, et al. Among authors: gilroy dw. Clin Pharmacol Ther. 2026 Mar;119(3):678-687. doi: 10.1002/cpt.70126. Epub 2025 Nov 15. Clin Pharmacol Ther. 2026. PMID: 41240016 Free PMC article.
194 results