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A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.
Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD. Van der Geize R, et al. Among authors: sim e. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1947-52. doi: 10.1073/pnas.0605728104. Epub 2007 Jan 30. Proc Natl Acad Sci U S A. 2007. PMID: 17264217 Free PMC article.
Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis.
Lack N, Lowe ED, Liu J, Eltis LD, Noble ME, Sim E, Westwood IM. Lack N, et al. Among authors: sim e. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jan 1;64(Pt 1):2-7. doi: 10.1107/S1744309107065931. Epub 2007 Dec 20. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18097091 Free PMC article.
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.
Ryan A, Polycarpou E, Lack NA, Evangelopoulos D, Sieg C, Halman A, Bhakta S, Eleftheriadou O, McHugh TD, Keany S, Lowe ED, Ballet R, Abuhammad A, Jacobs WR Jr, Ciulli A, Sim E. Ryan A, et al. Among authors: sim e. Br J Pharmacol. 2017 Jul;174(14):2209-2224. doi: 10.1111/bph.13810. Epub 2017 May 9. Br J Pharmacol. 2017. PMID: 28380256 Free PMC article.
706 results