Hruby V - Search Results

1

Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression.

Lee M, Kim A, Conwell IM, Hruby V, Mayorov A, Cai M, Wardlaw SL. Lee M, et al. Among authors: hruby v. Peptides. 2008 Mar;29(3):440-7. doi: 10.1016/j.peptides.2007.11.005. Epub 2007 Nov 21. Peptides. 2008. PMID: 18155809 Free PMC article.

2

Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors.

Cai M, Mayorov AV, Ying J, Stankova M, Trivedi D, Cabello C, Hruby VJ. Cai M, et al. Among authors: hruby vj. Peptides. 2005 Aug;26(8):1481-5. doi: 10.1016/j.peptides.2005.03.020. Peptides. 2005. PMID: 15876475 Review.

3

Structure-activity studies of new melanocortin peptides containing an aromatic amino acid at the N-terminal position.

Grieco P, Cai M, Mayorov AV, Trivedi D, Hruby VJ. Grieco P, et al. Among authors: hruby vj. Peptides. 2006 Feb;27(2):472-81. doi: 10.1016/j.peptides.2005.01.032. Epub 2005 Nov 21. Peptides. 2006. PMID: 16303211 Free PMC article.

4

Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.

Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ. Grieco P, et al. Peptides. 2007 Jun;28(6):1191-6. doi: 10.1016/j.peptides.2007.02.012. Epub 2007 Mar 1. Peptides. 2007. PMID: 17482720 Free PMC article.

5

Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor.

Hruby VJ, Cai M, Cain JP, Mayorov AV, Dedek MM, Trivedi D. Hruby VJ, et al. Curr Top Med Chem. 2007;7(11):1107-19. doi: 10.2174/156802607780906645. Curr Top Med Chem. 2007. PMID: 17584128 Free PMC article. Review.

6

Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors.

Mayorov AV, Cai M, Palmer ES, Liu Z, Cain JP, Vagner J, Trivedi D, Hruby VJ. Mayorov AV, et al. Among authors: hruby vj. Peptides. 2010 Oct;31(10):1894-905. doi: 10.1016/j.peptides.2010.06.026. Epub 2010 Aug 3. Peptides. 2010. PMID: 20688117 Free PMC article.

7

Key amino acid residues in the melanocortin-4 receptor for nonpeptide THIQ specific binding and signaling.

Yang Y, Cai M, Chen M, Qu H, McPherson D, Hruby V, Harmon CM. Yang Y, et al. Among authors: hruby v. Regul Pept. 2009 Jun 5;155(1-3):46-54. doi: 10.1016/j.regpep.2009.03.006. Epub 2009 Mar 20. Regul Pept. 2009. PMID: 19303903 Free PMC article.

8

Effects of macrocycle size and rigidity on melanocortin receptor-1 and -5 selectivity in cyclic lactam alpha-melanocyte-stimulating hormone analogs.

Mayorov AV, Han SY, Cai M, Hammer MR, Trivedi D, Hruby VJ. Mayorov AV, et al. Among authors: hruby vj. Chem Biol Drug Des. 2006 May;67(5):329-35. doi: 10.1111/j.1747-0285.2006.00383.x. Chem Biol Drug Des. 2006. PMID: 16784457 Free PMC article.

9

Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor.

Mayorov AV, Cai M, Palmer ES, Dedek MM, Cain JP, Van Scoy AR, Tan B, Vagner J, Trivedi D, Hruby VJ. Mayorov AV, et al. Among authors: hruby vj. J Med Chem. 2008 Jan 24;51(2):187-95. doi: 10.1021/jm070461w. Epub 2007 Dec 19. J Med Chem. 2008. PMID: 18088090 Free PMC article.

10

An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells.

Cai M, Stankova M, Muthu D, Mayorov A, Yang Z, Trivedi D, Cabello C, Hruby VJ. Cai M, et al. Biochemistry. 2013 Jan 29;52(4):752-64. doi: 10.1021/bi300723f. Epub 2013 Jan 15. Biochemistry. 2013. PMID: 23276279 Free PMC article.

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