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159 results

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Page 1
Inhibition of focal adhesion kinase impairs tumor formation and preserves hearing in a murine model of NF2-related schwannomatosis.
Mitchell DK, Brewster K, Jiang L, Mang H, Bessler WK, Li X, Lu Q, Qian S, York E, Morrow SK, Dixon SAH, Davis C, Chan KK, Smith A, Flint AC, Le VV, Geisinger A, Enane F, Nabet B, Rhodes SD, Angus SP, Clapp DW. Mitchell DK, et al. Among authors: clapp dw. Sci Adv. 2026 Jan 30;12(5):eady8382. doi: 10.1126/sciadv.ady8382. Epub 2026 Jan 30. Sci Adv. 2026. PMID: 41616055 Free PMC article.
Depletion of Fibrinogen Suppresses Growth of Primary Tumors and Metastasis of Pancreatic Ductal Adenocarcinoma.
Chowdhury NN, Mitchell DK, Kangro K, Eldridge K, Abrahams S, Ferraresso F, Juang LJ, Gampala S, Brewster K, Revenko A, Kastrup C, Territo PR, Clapp DW, Wang J, Belgodere JA, Saeed O, Choi SR, Han B, Wolberg AS, Cao S, Zhang C, Flick MJ, Fishel ML. Chowdhury NN, et al. Among authors: clapp dw. Gastroenterology. 2025 Dec 23:S0016-5085(25)06025-1. doi: 10.1053/j.gastro.2025.09.024. Online ahead of print. Gastroenterology. 2025. PMID: 41432649 Free article.
A haploinsufficiency restoration strategy corrects neurobehavioral deficits in Nf1+/- mice.
Park SJ, Lukkes JL, Chan KK, Drozd HP, Burgin CB, Qian S, Sullivan MM, Guevara CG, Cunningham N, Arenas S, Collins MA, Zucker J, Won J, Smith A, Jiang L, Mitchell DK, Rhodes SD, Angus SP, Clapp DW. Park SJ, et al. Among authors: clapp dw. J Clin Invest. 2025 Jul 1;135(13):e188932. doi: 10.1172/JCI188932. eCollection 2025 Jul 1. J Clin Invest. 2025. PMID: 40590220 Free PMC article.
TGFβ-dependent signaling drives tumor growth and aberrant extracellular matrix dynamics in NF1-associated plexiform neurofibroma.
Abu-Sultanah M, Zhou Z, Jiang C, Mitchell DK, Bessler WK, Jiang L, Li X, Qian S, Smith AE, Mang HE, White EE, Ciesielski MD, Hickey BE, Brewster KM, Sandusky GE, Masters A, Angus SP, Clapp DW, Le LQ, Rhodes SD. Abu-Sultanah M, et al. Among authors: clapp dw. Sci Adv. 2025 Jun 20;11(25):eadu0772. doi: 10.1126/sciadv.adu0772. Epub 2025 Jun 20. Sci Adv. 2025. PMID: 40540562 Free PMC article.
Effect of bevacizumab on non-target intracranial meningiomas and non-vestibular schwannomas in NF2-related schwannomatosis: NF104.
Nakhate V, Ly I, Muzikansky A, Rapalino O, Allen JC, Blakeley JO, Campian JL, Clapp DW, Dhall G, Jain RK, Karajannis MA, Packer RJ, Tonsgard J, Ullrich NJ, Korf BR, Fisher MJ, Plotkin SR; Neurofibromatosis Clinical Trials Consortium. Nakhate V, et al. Among authors: clapp dw. J Neurooncol. 2025 Jul;173(3):751-757. doi: 10.1007/s11060-025-05020-1. Epub 2025 May 28. J Neurooncol. 2025. PMID: 40434540 Clinical Trial.
Selumetinib in adults with NF1 and inoperable plexiform neurofibroma: a phase 2 trial.
Gross AM, O'Sullivan Coyne G, Dombi E, Tibery C, Herrick WG, Martin S, Angus SP, Shern JF, Rhodes SD, Foster JC, Rubinstein LV, Baldwin A, Davis C, Dixon SAH, Fagan M, Ong MJ, Wolters PL, Tamula MA, Reid O, Sankaran H, Fang F, Govindharajulu JP, Browne AT, Kaplan RN, Heisey K, On TJ, Xuei X, Zhang X, Johnson BC, Parchment RE, Clapp DW, Srivastava AK, Doroshow JH, Chen AP, Widemann BC. Gross AM, et al. Among authors: clapp dw. Nat Med. 2025 Jan;31(1):105-115. doi: 10.1038/s41591-024-03361-4. Epub 2025 Jan 6. Nat Med. 2025. PMID: 39762421 Free PMC article. Clinical Trial.
159 results