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Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia.
Jacob SA, Novelli EM, Isenberg JS, Garrett ME, Chu Y, Soldano K, Ataga KI, Telen MJ, Ashley-Koch A, Gladwin MT, Zhang Y, Kato GJ. Jacob SA, et al. Among authors: isenberg js. Am J Hematol. 2017 Mar;92(3):E31-E34. doi: 10.1002/ajh.24635. Epub 2017 Feb 3. Am J Hematol. 2017. PMID: 28033687 Free PMC article. Clinical Trial. No abstract available.
Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice.
Novelli EM, Little-Ihrig L, Knupp HE, Rogers NM, Yao M, Baust JJ, Meijles D, St Croix CM, Ross MA, Pagano PJ, DeVallance ER, Miles G, Potoka KP, Isenberg JS, Gladwin MT. Novelli EM, et al. Among authors: isenberg js. Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1150-L1164. doi: 10.1152/ajplung.00302.2018. Epub 2019 Mar 20. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 30892078 Free PMC article.
Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates.
Novelli EM, Kato GJ, Ragni MV, Zhang Y, Hildesheim ME, Nouraie M, Barge S, Meyer MP, Hassett AC, Gordeuk VR, Gladwin MT, Isenberg JS. Novelli EM, et al. Among authors: isenberg js. Am J Hematol. 2012 Mar;87(3):326-30. doi: 10.1002/ajh.22274. Epub 2012 Feb 8. Am J Hematol. 2012. PMID: 22318901 Free PMC article.
Cellular, pharmacological, and biophysical evaluation of explanted lungs from a patient with sickle cell disease and severe pulmonary arterial hypertension.
Rogers NM, Yao M, Sembrat J, George MP, Knupp H, Ross M, Sharifi-Sanjani M, Milosevic J, St Croix C, Rajkumar R, Frid MG, Hunter KS, Mazzaro L, Novelli EM, Stenmark KR, Gladwin MT, Ahmad F, Champion HC, Isenberg JS. Rogers NM, et al. Among authors: isenberg js. Pulm Circ. 2013 Dec;3(4):936-51. doi: 10.1086/674754. Pulm Circ. 2013. PMID: 25006410 Free PMC article.
Thrombospondin-1 inhibits ADAMTS13 activity in sickle cell disease.
Novelli EM, Kato GJ, Hildesheim ME, Barge S, Meyer MP, Lozier J, Hassett AC, Ragni MV, Isenberg JS, Gladwin MT. Novelli EM, et al. Among authors: isenberg js. Haematologica. 2013 Nov;98(11):e132-4. doi: 10.3324/haematol.2013.092635. Haematologica. 2013. PMID: 24186313 Free PMC article. No abstract available.
191 results