Gruber T - Search Results

1

The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.

Evenou JP, Wagner J, Zenke G, Brinkmann V, Wagner K, Kovarik J, Welzenbach KA, Weitz-Schmidt G, Guntermann C, Towbin H, Cottens S, Kaminski S, Letschka T, Lutz-Nicoladoni C, Gruber T, Hermann-Kleiter N, Thuille N, Baier G. Evenou JP, et al. Among authors: gruber t. J Pharmacol Exp Ther. 2009 Sep;330(3):792-801. doi: 10.1124/jpet.109.153205. Epub 2009 Jun 2. J Pharmacol Exp Ther. 2009. PMID: 19491325

2

Protein kinase Cepsilon is dispensable for TCR/CD3-signaling.

Gruber T, Thuille N, Hermann-Kleiter N, Leitges M, Baier G. Gruber T, et al. Mol Immunol. 2005 Feb;42(3):305-10. doi: 10.1016/j.molimm.2004.07.007. Mol Immunol. 2005. PMID: 15589318

3

Protein kinase C beta is dispensable for TCR-signaling.

Thuille N, Gruber T, Böck G, Leitges M, Baier G. Thuille N, et al. Among authors: gruber t. Mol Immunol. 2004 Jun;41(4):385-90. doi: 10.1016/j.molimm.2004.03.007. Mol Immunol. 2004. PMID: 15163535

4

Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells.

Pfeifhofer C, Kofler K, Gruber T, Tabrizi NG, Lutz C, Maly K, Leitges M, Baier G. Pfeifhofer C, et al. Among authors: gruber t. J Exp Med. 2003 Jun 2;197(11):1525-35. doi: 10.1084/jem.20020234. J Exp Med. 2003. PMID: 12782715 Free PMC article.

5

PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes.

Hermann-Kleiter N, Thuille N, Pfeifhofer C, Gruber T, Schäfer M, Zitt C, Hatzelmann A, Schudt C, Leitges M, Baier G. Hermann-Kleiter N, et al. Among authors: gruber t. Blood. 2006 Jun 15;107(12):4841-8. doi: 10.1182/blood-2005-10-4044. Epub 2006 Mar 2. Blood. 2006. PMID: 16514061 Free article.

6

Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation".

Gruber T, Freeley M, Thuille N, Heit I, Shaw S, Long A, Baier G. Gruber T, et al. Science. 2006 Apr 7;312(5770):55; author reply 55. doi: 10.1126/science.1115362. Science. 2006. PMID: 16601177

7

Defective IgG2a/2b class switching in PKC alpha-/- mice.

Pfeifhofer C, Gruber T, Letschka T, Thuille N, Lutz-Nicoladoni C, Hermann-Kleiter N, Braun U, Leitges M, Baier G. Pfeifhofer C, et al. Among authors: gruber t. J Immunol. 2006 May 15;176(10):6004-11. doi: 10.4049/jimmunol.176.10.6004. J Immunol. 2006. PMID: 16670309

8

The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity.

Hermann-Kleiter N, Gruber T, Lutz-Nicoladoni C, Thuille N, Fresser F, Labi V, Schiefermeier N, Warnecke M, Huber L, Villunger A, Eichele G, Kaminski S, Baier G. Hermann-Kleiter N, et al. Among authors: gruber t. Immunity. 2008 Aug 15;29(2):205-16. doi: 10.1016/j.immuni.2008.06.008. Immunity. 2008. PMID: 18701084 Free PMC article.

9

PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo.

Gruber T, Hermann-Kleiter N, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Thuille N, Letschka T, Barsig J, Baudler M, Li J, Metzler B, Nüsslein-Hildesheim B, Wagner J, Leitges M, Baier G. Gruber T, et al. Mol Immunol. 2009 Jun;46(10):2071-9. doi: 10.1016/j.molimm.2009.02.030. Epub 2009 Apr 7. Mol Immunol. 2009. PMID: 19356803

10

PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation.

Gruber T, Hermann-Kleiter N, Hinterleitner R, Fresser F, Schneider R, Gastl G, Penninger JM, Baier G. Gruber T, et al. Sci Signal. 2009 Jun 23;2(76):ra30. doi: 10.1126/scisignal.2000046. Sci Signal. 2009. PMID: 19549985

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