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A pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugs.
McCarthy JS, Sekuloski S, Griffin PM, Elliott S, Douglas N, Peatey C, Rockett R, O'Rourke P, Marquart L, Hermsen C, Duparc S, Möhrle J, Trenholme KR, Humberstone AJ. McCarthy JS, et al. PLoS One. 2011;6(8):e21914. doi: 10.1371/journal.pone.0021914. Epub 2011 Aug 22. PLoS One. 2011. PMID: 21887214 Free PMC article. Clinical Trial.
A phase 1 trial of MSP2-C1, a blood-stage malaria vaccine containing 2 isoforms of MSP2 formulated with Montanide® ISA 720.
McCarthy JS, Marjason J, Elliott S, Fahey P, Bang G, Malkin E, Tierney E, Aked-Hurditch H, Adda C, Cross N, Richards JS, Fowkes FJ, Boyle MJ, Long C, Druilhe P, Beeson JG, Anders RF. McCarthy JS, et al. PLoS One. 2011;6(9):e24413. doi: 10.1371/journal.pone.0024413. Epub 2011 Sep 19. PLoS One. 2011. PMID: 21949716 Free PMC article. Clinical Trial.
Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria.
Boyle MJ, Reiling L, Feng G, Langer C, Osier FH, Aspeling-Jones H, Cheng YS, Stubbs J, Tetteh KK, Conway DJ, McCarthy JS, Muller I, Marsh K, Anders RF, Beeson JG. Boyle MJ, et al. Among authors: mccarthy js. Immunity. 2015 Mar 17;42(3):580-90. doi: 10.1016/j.immuni.2015.02.012. Immunity. 2015. PMID: 25786180 Free PMC article. Clinical Trial.
Development of cultured Plasmodium falciparum blood-stage malaria cell banks for early phase in vivo clinical trial assessment of anti-malaria drugs and vaccines.
Stanisic DI, Liu XQ, De SL, Batzloff MR, Forbes T, Davis CB, Sekuloski S, Chavchich M, Chung W, Trenholme K, McCarthy JS, Li T, Sim BK, Hoffman SL, Good MF. Stanisic DI, et al. Among authors: mccarthy js. Malar J. 2015 Apr 7;14:143. doi: 10.1186/s12936-015-0663-x. Malar J. 2015. PMID: 25890156 Free PMC article.
Profoundly Reduced CD1c+ Myeloid Dendritic Cell HLA-DR and CD86 Expression and Increased Tumor Necrosis Factor Production in Experimental Human Blood-Stage Malaria Infection.
Loughland JR, Minigo G, Burel J, Tipping PE, Piera KA, Amante FH, Engwerda CR, Good MF, Doolan DL, Anstey NM, McCarthy JS, Woodberry T. Loughland JR, et al. Among authors: mccarthy js. Infect Immun. 2016 Apr 22;84(5):1403-1412. doi: 10.1128/IAI.01522-15. Print 2016 May. Infect Immun. 2016. PMID: 26902728 Free PMC article.
319 results