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Effect of the CYP3A inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of bortezomib in patients with advanced solid tumors: a prospective, multicenter, open-label, randomized, two-way crossover drug-drug interaction study.
Venkatakrishnan K, Rader M, Ramanathan RK, Ramalingam S, Chen E, Riordan W, Trepicchio W, Cooper M, Karol M, von Moltke L, Neuwirth R, Egorin M, Chatta G. Venkatakrishnan K, et al. Among authors: chen e. Clin Ther. 2009;31 Pt 2:2444-58. doi: 10.1016/j.clinthera.2009.11.012. Clin Ther. 2009. PMID: 20110052 Clinical Trial.
Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP-1 Transcription Factor ΔFOSB.
McNeme S, Yim YY, Kumar A, Li Y, Hughes B, St Romain CP, Aglyamova G, Chen J, Nguyen ND, Fan S, Stephens GS, Zhao WN, Kruzshak S, Estill M, Brener C, Tofani S, Kumar A, Chen EP, Takatka N, Robison AJ, Chen H, Powell RT, Haggarty SJ, Stephan C, Nestler EJ, Chin J, Machius M, Zhou J, Rudenko G. McNeme S, et al. Among authors: chen ep. J Biol Chem. 2025 Dec 22:111080. doi: 10.1016/j.jbc.2025.111080. Online ahead of print. J Biol Chem. 2025. PMID: 41443415 Free article.
Biomarkers.
Simmatis LE, Russo EE, Steininger T, Riddell H, Chen E, Chiu Q, Lin M, Oh D, Taheri P, Harmsen IE, Samuel N. Simmatis LE, et al. Among authors: chen e. Alzheimers Dement. 2025 Dec;21 Suppl 2(Suppl 2):e096963. doi: 10.1002/alz70856_096963. Alzheimers Dement. 2025. PMID: 41441813 Free PMC article.
Development and Validation of a Multimodal Artificial Intelligence-derived Digital Pathology-based Biomarker Predicting Metastasis Among Patients with Biochemical Recurrence After Radical Prostatectomy in NRG/RTOG Trials.
Morgan TM, Ren Y, Tang S, Zwerink W, Chen E, Mitani A, Huang HC, Simko JP, DeVries S, Pollack A, Wilke D, Martin AG, Balogh AG, Michalski JM, Greenberg MJ, Efstathiou JA, Bahary JP, Ross AE, Esteva A, Royce TJ, Nguyen PL, Hoffman KE, Sandler HM, Tran PT, Pugh SL, Feng FY, Spratt DE. Morgan TM, et al. Among authors: chen e. Eur Urol. 2025 Dec 22:S0302-2838(25)04859-6. doi: 10.1016/j.eururo.2025.12.007. Online ahead of print. Eur Urol. 2025. PMID: 41436315
Hepatic adaptation to chronic metabolic stress primes tumorigenesis.
Tzouanas CN, Shay JES, Sherman MS, Rubin AJ, Mead BE, Dao TT, Tao J, Lehrich BM, Eng G, Patterson-Fortin J, Butzlaff T, Mana MD, Kolb KE, Walesky C, Pepe-Mooney BJ, Smith CJ, Prakadan SM, Ramseier ML, Tong YE, Joung J, Chi F, McMahon-Skates T, Winston CL, Jeong WJ, Aney KJ, Chen E, Nissim S, Zhang F, Deshpande V, Monga SP, Lauer GM, Goessling W, Yilmaz ÖH, Shalek AK. Tzouanas CN, et al. Among authors: chen e. Cell. 2025 Dec 22:S0092-8674(25)01366-2. doi: 10.1016/j.cell.2025.11.031. Online ahead of print. Cell. 2025. PMID: 41435820
6,637 results