Appleton PL - Search Results

1

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

Quyn AJ, Appleton PL, Carey FA, Steele RJ, Barker N, Clevers H, Ridgway RA, Sansom OJ, Näthke IS. Quyn AJ, et al. Among authors: appleton pl. Cell Stem Cell. 2010 Feb 5;6(2):175-81. doi: 10.1016/j.stem.2009.12.007. Cell Stem Cell. 2010. PMID: 20144789 Free article.

2

Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection.

Newton IP, Kenneth NS, Appleton PL, Näthke I, Rocha S. Newton IP, et al. Among authors: appleton pl. Mol Biol Cell. 2010 Nov 1;21(21):3630-8. doi: 10.1091/mbc.E10-04-0312. Epub 2010 Sep 15. Mol Biol Cell. 2010. PMID: 20844082 Free PMC article.

3

The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively.

Klotz DM, Nelson SA, Kroboth K, Newton IP, Radulescu S, Ridgway RA, Sansom OJ, Appleton PL, Näthke IS. Klotz DM, et al. Among authors: appleton pl. J Cell Sci. 2012 Feb 15;125(Pt 4):887-95. doi: 10.1242/jcs.091843. Epub 2012 Mar 7. J Cell Sci. 2012. PMID: 22399804 Free PMC article.

4

Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lost.

Fatehullah A, Appleton PL, Näthke IS. Fatehullah A, et al. Among authors: appleton pl. Philos Trans R Soc Lond B Biol Sci. 2013 Sep 23;368(1629):20130014. doi: 10.1098/rstb.2013.0014. Print 2013. Philos Trans R Soc Lond B Biol Sci. 2013. PMID: 24062584 Free PMC article.

5

Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol.

Radulescu S, Ridgway RA, Appleton P, Kroboth K, Patel S, Woodgett J, Taylor S, Nathke IS, Sansom OJ. Radulescu S, et al. Oncogene. 2010 Dec 9;29(49):6418-27. doi: 10.1038/onc.2010.373. Epub 2010 Aug 23. Oncogene. 2010. PMID: 20729907 Free PMC article.

6

Combined changes in Wnt signaling response and contact inhibition induce altered proliferation in radiation-treated intestinal crypts.

Dunn SJ, Osborne JM, Appleton PL, Näthke I. Dunn SJ, et al. Among authors: appleton pl. Mol Biol Cell. 2016 Jun 1;27(11):1863-74. doi: 10.1091/mbc.E15-12-0854. Epub 2016 Apr 6. Mol Biol Cell. 2016. PMID: 27053661 Free PMC article.

7

Increased variability in Apc(Min)/+ intestinal tissue can be measured with microultrasound.

Fatehullah A, Sharma S, Newton IP, Langlands AJ, Lay H, Nelson SA, McMahon RK, McIlvenny N, Appleton PL, Cochran S, Näthke IS. Fatehullah A, et al. Among authors: appleton pl. Sci Rep. 2016 Jul 13;6:29570. doi: 10.1038/srep29570. Sci Rep. 2016. PMID: 27406832 Free PMC article.

8

Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems.

Nelson SA, Li Z, Newton IP, Fraser D, Milne RE, Martin DM, Schiffmann D, Yang X, Dormann D, Weijer CJ, Appleton PL, Näthke IS. Nelson SA, et al. Among authors: appleton pl. Dis Model Mech. 2012 Nov;5(6):940-7. doi: 10.1242/dmm.008607. Epub 2012 Apr 5. Dis Model Mech. 2012. PMID: 22563063 Free PMC article.

9

Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche.

Langlands AJ, Almet AA, Appleton PL, Newton IP, Osborne JM, Näthke IS. Langlands AJ, et al. Among authors: appleton pl. PLoS Biol. 2016 Jun 27;14(6):e1002491. doi: 10.1371/journal.pbio.1002491. eCollection 2016 Jun. PLoS Biol. 2016. PMID: 27348469 Free PMC article.

10

Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids.

Carroll TD, Langlands AJ, Osborne JM, Newton IP, Appleton PL, Näthke I. Carroll TD, et al. Among authors: appleton pl. J Cell Sci. 2017 Nov 15;130(22):3862-3877. doi: 10.1242/jcs.211656. Epub 2017 Oct 5. J Cell Sci. 2017. PMID: 28982714 Free PMC article.

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