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Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.
Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT. Wu HY, et al. Among authors: hashimoto t. J Neurosci. 2010 Feb 17;30(7):2636-49. doi: 10.1523/JNEUROSCI.4456-09.2010. J Neurosci. 2010. PMID: 20164348 Free PMC article.
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques.
Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL. Koffie RM, et al. Among authors: hashimoto t. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):4012-7. doi: 10.1073/pnas.0811698106. Epub 2009 Feb 19. Proc Natl Acad Sci U S A. 2009. PMID: 19228947 Free PMC article.
Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice.
DaRocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, Rodríguez M, Sánchez B, Hyman BT, Gómez-Isla T. DaRocha-Souto B, et al. Among authors: hashimoto t. J Neuropathol Exp Neurol. 2011 May;70(5):360-76. doi: 10.1097/NEN.0b013e318217a118. J Neuropathol Exp Neurol. 2011. PMID: 21487307 Free PMC article.
Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease.
DaRocha-Souto B, Coma M, Pérez-Nievas BG, Scotton TC, Siao M, Sánchez-Ferrer P, Hashimoto T, Fan Z, Hudry E, Barroeta I, Serenó L, Rodríguez M, Sánchez MB, Hyman BT, Gómez-Isla T. DaRocha-Souto B, et al. Among authors: hashimoto t. Neurobiol Dis. 2012 Jan;45(1):425-37. doi: 10.1016/j.nbd.2011.09.002. Epub 2011 Sep 13. Neurobiol Dis. 2012. PMID: 21945540 Free PMC article.
7,216 results