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Discovery of Bis-Acyl Hydrazides as Potent and Bioavailable MTA-Cooperative PRMT5 Inhibitors: A Case Study of Leveraging the Deuterium Kinetic Isotope Effect.
Debien L, Armstrong MK, Farr JD, Ferrao RD, Gupta PL, Niu C, Anderson AJ, Benner P, Bristol AN, Chin E, Chou C, Deng Y, Fu X, Gheiratmand M, Hull SM, Hung JC, June B, Kirschman JH, Le H, Malik B, Mitchell ML, Mukherjee PK, Nguyen SV, Notte GT, Orf J, Roa DE, Santos R, Schrier AJ, Spence KA, Sura R, Yang ZY, Zane D, Zahabian AN, Zavorotinskaya T. Debien L, et al. Among authors: mitchell ml. J Med Chem. 2025 Dec 22. doi: 10.1021/acs.jmedchem.5c02392. Online ahead of print. J Med Chem. 2025. PMID: 41429045
203 results