Perlmutter P - Search Results

1

β-Amino acid substitution to investigate the recognition of angiotensin II (AngII) by angiotensin converting enzyme 2 (ACE2).

Clayton D, Hanchapola I, Hausler N, Unabia S, Lew RA, Widdop RE, Smith AI, Perlmutter P, Aguilar MI. Clayton D, et al. Among authors: perlmutter p. J Mol Recognit. 2011 Mar-Apr;24(2):235-44. doi: 10.1002/jmr.1041. J Mol Recognit. 2011. PMID: 20549604

2

Inhibitors of metalloendopeptidase EC 3.4.24.15 and EC 3.4.24.16 stabilized against proteolysis by the incorporation of beta-amino acids.

Steer D, Lew R, Perlmutter P, Smith AI, Aguilar MI. Steer D, et al. Among authors: perlmutter p. Biochemistry. 2002 Sep 3;41(35):10819-26. doi: 10.1021/bi0203334. Biochemistry. 2002. PMID: 12196021

3

The active site specificity of angiotensin II converting enzyme 2 investigated through single and multiple residue changes and beta-amino acid substrate analogs.

Clayton D, Hanchapola I, Perlmutter P, Smith AI, Aguilar MI. Clayton D, et al. Among authors: perlmutter p. Adv Exp Med Biol. 2009;611:559-60. doi: 10.1007/978-0-387-73657-0_245. Adv Exp Med Biol. 2009. PMID: 19400312 No abstract available.

4

A single beta-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function.

Jones ES, Del Borgo MP, Kirsch JF, Clayton D, Bosnyak S, Welungoda I, Hausler N, Unabia S, Perlmutter P, Thomas WG, Aguilar MI, Widdop RE. Jones ES, et al. Among authors: perlmutter p. Hypertension. 2011 Mar;57(3):570-6. doi: 10.1161/HYPERTENSIONAHA.110.164301. Epub 2011 Feb 7. Hypertension. 2011. PMID: 21300665

5

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2.

Clayton D, Hanchapola I, Thomas WG, Widdop RE, Smith AI, Perlmutter P, Aguilar MI. Clayton D, et al. Among authors: perlmutter p. Front Pharmacol. 2015 Jan 30;6:5. doi: 10.3389/fphar.2015.00005. eCollection 2015. Front Pharmacol. 2015. PMID: 25688208 Free PMC article.

6

Beta-amino acids: versatile peptidomimetics.

Steer DL, Lew RA, Perlmutter P, Smith AI, Aguilar MI. Steer DL, et al. Among authors: perlmutter p. Curr Med Chem. 2002 Apr;9(8):811-22. doi: 10.2174/0929867024606759. Curr Med Chem. 2002. PMID: 11966446 Review.

7

Beta-amino acid-containing hybrid peptides--new opportunities in peptidomimetics.

Aguilar MI, Purcell AW, Devi R, Lew R, Rossjohn J, Smith AI, Perlmutter P. Aguilar MI, et al. Among authors: perlmutter p. Org Biomol Chem. 2007 Sep 21;5(18):2884-90. doi: 10.1039/b708507a. Epub 2007 Aug 3. Org Biomol Chem. 2007. PMID: 17728852

8

Conformational stability studies of a stapled hexa-β3-peptide library.

Gopalan RD, Del Borgo MP, Bergman YE, Unabia S, Mulder RJ, Wilce MC, Wilce JA, Aguilar MI, Perlmutter P. Gopalan RD, et al. Among authors: perlmutter p. Org Biomol Chem. 2012 Mar 7;10(9):1802-6. doi: 10.1039/c2ob06617c. Epub 2012 Jan 18. Org Biomol Chem. 2012. PMID: 22252416

9

Single β³-amino acid substitutions to MOG peptides suppress the development of experimental autoimmune encephalomyelitis.

McDonald CA, Payne NL, Sun G, Clayton DJ, Del Borgo MP, Aguilar MI, Perlmutter P, Bernard CC. McDonald CA, et al. Among authors: perlmutter p. J Neuroimmunol. 2014 Dec 15;277(1-2):67-76. doi: 10.1016/j.jneuroim.2014.09.022. Epub 2014 Oct 8. J Neuroimmunol. 2014. PMID: 25454728

10

β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats.

Del Borgo M, Wang Y, Bosnyak S, Khan M, Walters P, Spizzo I, Perlmutter P, Hilliard L, Denton K, Aguilar MI, Widdop RE, Jones ES. Del Borgo M, et al. Among authors: perlmutter p. Clin Sci (Lond). 2015 Sep;129(6):505-13. doi: 10.1042/CS20150077. Epub 2015 May 8. Clin Sci (Lond). 2015. PMID: 26186568

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