Perlmutter DH - Search Results

1

Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes.

Ding J, Yannam GR, Roy-Chowdhury N, Hidvegi T, Basma H, Rennard SI, Wong RJ, Avsar Y, Guha C, Perlmutter DH, Fox IJ, Roy-Chowdhury J. Ding J, et al. Among authors: perlmutter dh. J Clin Invest. 2011 May;121(5):1930-4. doi: 10.1172/JCI45260. Epub 2011 Apr 18. J Clin Invest. 2011. PMID: 21505264 Free PMC article.

2

Induced pluripotent stem cells model personalized variations in liver disease resulting from α1-antitrypsin deficiency.

Tafaleng EN, Chakraborty S, Han B, Hale P, Wu W, Soto-Gutierrez A, Feghali-Bostwick CA, Wilson AA, Kotton DN, Nagaya M, Strom SC, Roy-Chowdhury J, Stolz DB, Perlmutter DH, Fox IJ. Tafaleng EN, et al. Among authors: perlmutter dh. Hepatology. 2015 Jul;62(1):147-57. doi: 10.1002/hep.27753. Epub 2015 Apr 13. Hepatology. 2015. PMID: 25690322 Free PMC article.

3

Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity.

Kamimoto T, Shoji S, Hidvegi T, Mizushima N, Umebayashi K, Perlmutter DH, Yoshimori T. Kamimoto T, et al. Among authors: perlmutter dh. J Biol Chem. 2006 Feb 17;281(7):4467-76. doi: 10.1074/jbc.M509409200. Epub 2005 Dec 19. J Biol Chem. 2006. PMID: 16365039 Free article.

4

The role of autophagy in alpha-1-antitrypsin deficiency.

Hidvegi T, Mukherjee A, Ewing M, Kemp C, Perlmutter DH. Hidvegi T, et al. Among authors: perlmutter dh. Methods Enzymol. 2011;499:33-54. doi: 10.1016/B978-0-12-386471-0.00003-1. Methods Enzymol. 2011. PMID: 21683248

5

Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.

Hidvegi T, Schmidt BZ, Hale P, Perlmutter DH. Hidvegi T, et al. Among authors: perlmutter dh. J Biol Chem. 2005 Nov 25;280(47):39002-15. doi: 10.1074/jbc.M508652200. Epub 2005 Sep 23. J Biol Chem. 2005. PMID: 16183649 Free article.

6

Regulator of G Signaling 16 is a marker for the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency.

Hidvegi T, Mirnics K, Hale P, Ewing M, Beckett C, Perlmutter DH. Hidvegi T, et al. Among authors: perlmutter dh. J Biol Chem. 2007 Sep 21;282(38):27769-80. doi: 10.1074/jbc.M704330200. Epub 2007 Jul 17. J Biol Chem. 2007. PMID: 17635928 Free article.

7

Regulation of PGC1α Downstream of the Insulin Signaling Pathway Plays a Role in the Hepatic Proteotoxicity of Mutant α1-Antitrypsin Deficiency Variant Z.

Rudnick DA, Huang J, Hidvegi T, Chu AS, Hale P, Munanairi A, Dietzen DJ, Cliften PF, Tycksen E, Lutkewitte AJ, Finck BN, Pak SC, Silverman GA, Perlmutter DH. Rudnick DA, et al. Among authors: perlmutter dh. Gastroenterology. 2022 Jul;163(1):270-284. doi: 10.1053/j.gastro.2022.03.010. Epub 2022 Mar 15. Gastroenterology. 2022. PMID: 35301011 Free PMC article.

8

NFκB mitigates the pathological effects of misfolded α1-antitrypsin by activating autophagy and an integrated program of proteostasis mechanisms.

Mukherjee A, Hidvegi T, Araya P, Ewing M, Stolz DB, Perlmutter DH. Mukherjee A, et al. Among authors: perlmutter dh. Cell Death Differ. 2019 Mar;26(3):455-469. doi: 10.1038/s41418-018-0130-7. Epub 2018 May 23. Cell Death Differ. 2019. PMID: 29795336 Free PMC article.

9

An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis.

Hidvegi T, Ewing M, Hale P, Dippold C, Beckett C, Kemp C, Maurice N, Mukherjee A, Goldbach C, Watkins S, Michalopoulos G, Perlmutter DH. Hidvegi T, et al. Among authors: perlmutter dh. Science. 2010 Jul 9;329(5988):229-32. doi: 10.1126/science.1190354. Epub 2010 Jun 3. Science. 2010. PMID: 20522742

10

The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.

Teckman JH, Burrows J, Hidvegi T, Schmidt B, Hale PD, Perlmutter DH. Teckman JH, et al. Among authors: perlmutter dh. J Biol Chem. 2001 Nov 30;276(48):44865-72. doi: 10.1074/jbc.M103703200. Epub 2001 Sep 27. J Biol Chem. 2001. PMID: 11577074 Free article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

177 results

Search Page

Filters