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The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: a Leu-12 to Pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in prosegment removal.
Stack CM, Donnelly S, Lowther J, Xu W, Collins PR, Brinen LS, Dalton JP. Stack CM, et al. J Biol Chem. 2007 Jun 1;282(22):16532-43. doi: 10.1074/jbc.M611501200. Epub 2007 Apr 2. J Biol Chem. 2007. PMID: 17403677 Free article.
Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines.
Dalton JP, Neill SO, Stack C, Collins P, Walshe A, Sekiya M, Doyle S, Mulcahy G, Hoyle D, Khaznadji E, Moiré N, Brennan G, Mousley A, Kreshchenko N, Maule AG, Donnelly SM. Dalton JP, et al. Among authors: stack c. Int J Parasitol. 2003 Sep 30;33(11):1173-81. doi: 10.1016/s0020-7519(03)00171-1. Int J Parasitol. 2003. PMID: 13678633 Review.
194 results