Spring DR - Search Results

1

Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site.

Bolanos-Garcia VM, Lischetti T, Matak-Vinković D, Cota E, Simpson PJ, Chirgadze DY, Spring DR, Robinson CV, Nilsson J, Blundell TL. Bolanos-Garcia VM, et al. Among authors: spring dr. Structure. 2011 Nov 9;19(11):1691-700. doi: 10.1016/j.str.2011.09.017. Epub 2011 Oct 13. Structure. 2011. PMID: 22000412 Free PMC article.

2

Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design.

Curran PR, Radoux CJ, Smilova MD, Sykes RA, Higueruelo AP, Bradley AR, Marsden BD, Spring DR, Blundell TL, Leach AR, Pitt WR, Cole JC. Curran PR, et al. Among authors: spring dr. J Chem Inf Model. 2020 Apr 27;60(4):1911-1916. doi: 10.1021/acs.jcim.9b00996. Epub 2020 Apr 2. J Chem Inf Model. 2020. PMID: 32207937

3

Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents.

Stockwell SR, Scott DE, Fischer G, Guarino E, Rooney TPC, Feng TS, Moschetti T, Srinivasan R, Alza E, Asteian A, Dagostin C, Alcaide A, Rocaboy M, Blaszczyk B, Higueruelo A, Wang X, Rossmann M, Perrior TR, Blundell TL, Spring DR, McKenzie G, Abell C, Skidmore J, Venkitaraman AR, Hyvönen M. Stockwell SR, et al. Among authors: spring dr. J Med Chem. 2024 Sep 12;67(17):15521-15536. doi: 10.1021/acs.jmedchem.4c01165. Epub 2024 Aug 27. J Med Chem. 2024. PMID: 39190548 Free PMC article.

4

Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.

Janeček M, Rossmann M, Sharma P, Emery A, Huggins DJ, Stockwell SR, Stokes JE, Tan YS, Almeida EG, Hardwick B, Narvaez AJ, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR. Janeček M, et al. Among authors: spring dr. Sci Rep. 2016 Jun 24;6:28528. doi: 10.1038/srep28528. Sci Rep. 2016. PMID: 27339427 Free PMC article.

5

Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.

Wu Y, Villa F, Maman J, Lau YH, Dobnikar L, Simon AC, Labib K, Spring DR, Pellegrini L. Wu Y, et al. Among authors: spring dr. Angew Chem Int Ed Engl. 2017 Oct 9;56(42):12866-12872. doi: 10.1002/anie.201705611. Epub 2017 Sep 7. Angew Chem Int Ed Engl. 2017. PMID: 28815832

6

A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.

Sharma P, Mahen R, Rossmann M, Stokes JE, Hardwick B, Huggins DJ, Emery A, Kunciw DL, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR. Sharma P, et al. Among authors: spring dr. Sci Rep. 2019 Nov 4;9(1):15930. doi: 10.1038/s41598-019-50702-2. Sci Rep. 2019. PMID: 31685831 Free PMC article.

7

Design and chance in the self-assembly of macromolecules.

Worrall JA, Górna M, Pei XY, Spring DR, Nicholson RL, Luisi BF. Worrall JA, et al. Among authors: spring dr. Biochem Soc Trans. 2007 Jun;35(Pt 3):502-7. doi: 10.1042/BST0350502. Biochem Soc Trans. 2007. PMID: 17511639 Review.

8

Mastering the chemical language of bacteria.

Galloway WR, Hodgkinson JT, Welch M, Spring DR. Galloway WR, et al. Among authors: spring dr. Chem Biol. 2009 Sep 25;16(9):913-4. doi: 10.1016/j.chembiol.2009.09.006. Chem Biol. 2009. PMID: 19778715

9

Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1.

Tan YS, Śledź P, Lang S, Stubbs CJ, Spring DR, Abell C, Best RB. Tan YS, et al. Among authors: spring dr. Angew Chem Int Ed Engl. 2012 Oct 1;51(40):10078-81. doi: 10.1002/anie.201205676. Epub 2012 Sep 7. Angew Chem Int Ed Engl. 2012. PMID: 22961729 Free PMC article. No abstract available.

10

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.

De Fusco C, Brear P, Iegre J, Georgiou KH, Sore HF, Hyvönen M, Spring DR. De Fusco C, et al. Among authors: spring dr. Bioorg Med Chem. 2017 Jul 1;25(13):3471-3482. doi: 10.1016/j.bmc.2017.04.037. Epub 2017 Apr 30. Bioorg Med Chem. 2017. PMID: 28495381 Free PMC article.

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