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Page 1
Intra-subtype heterogeneity shapes treatment response in KMT2A-rearranged ALL across all age groups.
Hartmann AM, Bastian L, Barz MJ, Haas J, Amelunxen E, Ehm P, Lenk L, Kotrova M, Beder T, Steffen FD, Rauwolf K, Wolgast N, Bendig S, Bozzetti C, Alten J, Mondal M, Rademacher A, Heymann J, Walter W, Haferlach C, Ströh AS, Bergmann AK, Burmeister T, Gökbuget N, Bornhauser B, Bourquin JP, Brüggemann M, Schrappe M, Cario G, Baldus CD. Hartmann AM, et al. Among authors: bornhauser b. Hemasphere. 2026 Feb 19;10(2):e70324. doi: 10.1002/hem3.70324. eCollection 2026 Feb. Hemasphere. 2026. PMID: 41743263 Free PMC article.
Functional precision approach in patients with very high risk acute lymphoblastic leukaemia in India: a single-centre cohort study.
Sidhu J, Chakraborty A, Das P, Steffen FD, Kundu S, Basu S, Tarafdar B, Dey T, Kar A, Biswas M, Das A, Sivadasan N, Dasgupta P, Ghara N, Bornhauser B, Bourquin JP, Krishnan S, Saha V. Sidhu J, et al. Among authors: bornhauser b. Lancet Reg Health Southeast Asia. 2026 Jan 2;44:100710. doi: 10.1016/j.lansea.2025.100710. eCollection 2026 Jan. Lancet Reg Health Southeast Asia. 2026. PMID: 41551378 Free PMC article.
A clinical-stage oncology compound selectively targets drug-resistant cancers.
Long K, Bhattacharjee D, Newman-Stonebraker SH, Suhr S, Mercado BQ, Scheib E, Tighe A, Romero L, Thompson SL, Sausville EL, John KM, Julian L, Mishra S, Klingbeil O, Gupta P, Bhatt U, Gao AC, Ricardo S, Vakoc CR, Bornhauser BC, Corsello SM, Taylor SS, Chen J, Holland PL, Sheltzer JM. Long K, et al. Among authors: bornhauser bc. bioRxiv [Preprint]. 2026 Feb 3:2025.11.26.690878. doi: 10.1101/2025.11.26.690878. bioRxiv. 2026. PMID: 41394735 Free PMC article. Preprint.
Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12.
Troester S, Eder T, Wukowits N, Piontek M, Fernández-Pernas P, Schmoellerl J, Haladik B, Manhart G, Allram M, Maurer-Granofszky M, Scheidegger N, Nebral K, Superti-Furga G, Meisel R, Bornhauser B, Valent P, Dworzak MN, Zuber J, Boztug K, Grebien F. Troester S, et al. Among authors: bornhauser b. Nat Commun. 2025 May 19;16(1):4656. doi: 10.1038/s41467-025-59930-9. Nat Commun. 2025. PMID: 40389480 Free PMC article.
SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response.
Ibrahim NK, Schreek S, Cinar B, Stasche AS, Lee SH, Zeug A, Dolgner T, Niessen J, Ponimaskin E, Shcherbata H, Fehlhaber B, Bourquin JP, Bornhauser B, Stanulla M, Pich A, Gutierrez A, Hinze L. Ibrahim NK, et al. Among authors: bornhauser b. Cell Rep. 2025 Apr 22;44(4):115434. doi: 10.1016/j.celrep.2025.115434. Epub 2025 Mar 24. Cell Rep. 2025. PMID: 40131931 Free PMC article.
IAP dependency of T-cell prolymphocytic leukemia identified by high-throughput drug screening.
Pohly MF, Putzker K, Scheinost S, Ben Taarit L, Walther T, Kummer S, Wertheimer T, Lin M, Do THL, Handler K, Michler J, Kivioja J, Bach K, Kisele S, Kim J, Dietrich S, Bornhauser B, Wong WW, Becher B, Moor A, Lewis J, Ficht X, Lu J, Huber W, Zenz T. Pohly MF, et al. Among authors: bornhauser b. Blood. 2025 May 15;145(20):2336-2352. doi: 10.1182/blood.2024027171. Blood. 2025. PMID: 39869826
96 results