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Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome.
Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, Ulland TK, Eisenbarth SC, Florquin S, Flavell RA, Leemans JC, Sutterwala FS. Iyer SS, et al. Among authors: sutterwala fs. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20388-93. doi: 10.1073/pnas.0908698106. Epub 2009 Nov 16. Proc Natl Acad Sci U S A. 2009. PMID: 19918053 Free PMC article.
Sensing damage by the NLRP3 inflammasome.
Leemans JC, Cassel SL, Sutterwala FS. Leemans JC, et al. Among authors: sutterwala fs. Immunol Rev. 2011 Sep;243(1):152-62. doi: 10.1111/j.1600-065X.2011.01043.x. Immunol Rev. 2011. PMID: 21884174 Free PMC article. Review.
NALP3: a key player in caspase-1 activation.
Sutterwala FS, Ogura Y, Zamboni DS, Roy CR, Flavell RA. Sutterwala FS, et al. J Endotoxin Res. 2006;12(4):251-6. doi: 10.1177/09680519060120040701. J Endotoxin Res. 2006. PMID: 16953978
118 results