Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome.
Ghosh A, Ahmed A, Amoiradaki K, Balazs AYS, Barlaam B, Bodnarchuk MS, Collie GW, Dale IL, Denz CR, Drew L, Edmondson SD, Fan J, Fawell S, Goldberg FW, Gopalsamy A, Grondine M, Guo G, Hande SM, Hatoum-Mokdad H, Hird AW, Howells R, Hao-Ru Hsu J, Hudson J, Jackson A, Lamb ML, Lamont GM, Lamont S, Lichtor PA, McWilliams L, Milne D, Mlynarski SN, Narasimhan P, Peters MF, Pflug A, Pollard HK, Qin M, Reimer C, Robbins KJ, Robinson J, Sha L, She H, Sheppeck JE 2nd, Singh B, Song K, Su Q, Telmesani R, Throner S, Vasalou C, Wang L, Wang Y, Wilson DM, Winlow P, Yang W, Yao T, Zhang Y, Zhang Z, Zindel D, Johannes JW.
Ghosh A, et al. Among authors: howells r.
J Med Chem. 2025 Sep 11;68(17):18164-18177. doi: 10.1021/acs.jmedchem.5c01478. Epub 2025 Sep 3.
J Med Chem. 2025.
PMID: 40899577