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Page 1
Genes related to emphysema are enriched for ubiquitination pathways.
Stepaniants S, Wang IM, Boie Y, Mortimer J, Kennedy B, Elliott M, Hayashi S, Luo H, Wong J, Loy L, Coulter S, Roberts CJ, Hogg JC, Sin DD, O'Neill G, Crackower M, Morris M, Paré PD, Obeidat M. Stepaniants S, et al. Among authors: crackower m. BMC Pulm Med. 2014 Nov 29;14:187. doi: 10.1186/1471-2466-14-187. BMC Pulm Med. 2014. PMID: 25432663 Free PMC article.
Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer.
Wang IM, Stepaniants S, Boie Y, Mortimer JR, Kennedy B, Elliott M, Hayashi S, Loy L, Coulter S, Cervino S, Harris J, Thornton M, Raubertas R, Roberts C, Hogg JC, Crackower M, O'Neill G, Paré PD. Wang IM, et al. Among authors: crackower m. Am J Respir Crit Care Med. 2008 Feb 15;177(4):402-11. doi: 10.1164/rccm.200703-390OC. Epub 2007 Nov 1. Am J Respir Crit Care Med. 2008. PMID: 17975202
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers.
Wang IM, Zhang B, Yang X, Zhu J, Stepaniants S, Zhang C, Meng Q, Peters M, He Y, Ni C, Slipetz D, Crackower MA, Houshyar H, Tan CM, Asante-Appiah E, O'Neill G, Luo MJ, Thieringer R, Yuan J, Chiu CS, Lum PY, Lamb J, Boie Y, Wilkinson HA, Schadt EE, Dai H, Roberts C. Wang IM, et al. Among authors: crackower ma. Mol Syst Biol. 2012 Jul 17;8:594. doi: 10.1038/msb.2012.24. Mol Syst Biol. 2012. PMID: 22806142 Free PMC article.
Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.
Gallant M, Beaulieu C, Berthelette C, Colucci J, Crackower MA, Dalton C, Denis D, Ducharme Y, Friesen RW, Guay D, Gervais FG, Hamel M, Houle R, Krawczyk CM, Kosjek B, Lau S, Leblanc Y, Lee EE, Levesque JF, Mellon C, Molinaro C, Mullet W, O'Neill GP, O'Shea P, Sawyer N, Sillaots S, Simard D, Slipetz D, Stocco R, Sørensen D, Truong VL, Wong E, Wu J, Zaghdane H, Wang Z. Gallant M, et al. Among authors: crackower ma. Bioorg Med Chem Lett. 2011 Jan 1;21(1):288-93. doi: 10.1016/j.bmcl.2010.11.015. Epub 2010 Nov 5. Bioorg Med Chem Lett. 2011. PMID: 21106375
Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist.
Gervais FG, Sawyer N, Stocco R, Hamel M, Krawczyk C, Sillaots S, Denis D, Wong E, Wang Z, Gallant M, Abraham WM, Slipetz D, Crackower MA, O'Neill GP. Gervais FG, et al. Among authors: crackower ma. Mol Pharmacol. 2011 Jan;79(1):69-76. doi: 10.1124/mol.110.068585. Epub 2010 Oct 13. Mol Pharmacol. 2011. PMID: 20943773
A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system.
St Pierre C, Guo J, Shin JD, Engstrom LW, Lee HH, Herbert A, Surdi L, Baker J, Salmon M, Shah S, Ellis JM, Houshyar H, Crackower MA, Kleinschek MA, Jones DC, Hicks A, Zaller DM, Alves SE, Ramadas RA. St Pierre C, et al. Among authors: crackower ma. PLoS One. 2017 Jul 18;12(7):e0180870. doi: 10.1371/journal.pone.0180870. eCollection 2017. PLoS One. 2017. PMID: 28719615 Free PMC article.
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