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Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation.

Kaushal V, Dye R, Pakavathkumar P, Foveau B, Flores J, Hyman B, Ghetti B, Koller BH, LeBlanc AC. Kaushal V, et al. Among authors: pakavathkumar p. Cell Death Differ. 2015 Oct;22(10):1676-86. doi: 10.1038/cdd.2015.16. Epub 2015 Mar 6. Cell Death Differ. 2015. PMID: 25744023 Free PMC article.

Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment.

LeBlanc AC, Ramcharitar J, Afonso V, Hamel E, Bennett DA, Pakavathkumar P, Albrecht S. LeBlanc AC, et al. Among authors: pakavathkumar p. Cell Death Differ. 2014 May;21(5):696-706. doi: 10.1038/cdd.2013.194. Epub 2014 Jan 10. Cell Death Differ. 2014. PMID: 24413155 Free PMC article.

Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine.

Pakavathkumar P, Sharma G, Kaushal V, Foveau B, LeBlanc AC. Pakavathkumar P, et al. Sci Rep. 2015 Sep 24;5:13730. doi: 10.1038/srep13730. Sci Rep. 2015. PMID: 26400108 Free PMC article.

Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.

Pakavathkumar P, Noël A, Lecrux C, Tubeleviciute-Aydin A, Hamel E, Ahlfors JE, LeBlanc AC. Pakavathkumar P, et al. Mol Neurodegener. 2017 Feb 28;12(1):22. doi: 10.1186/s13024-017-0166-z. Mol Neurodegener. 2017. PMID: 28241839 Free PMC article.

Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype.

Allard S, Leon WC, Pakavathkumar P, Bruno MA, Ribeiro-da-Silva A, Cuello AC. Allard S, et al. Among authors: pakavathkumar p. J Neurosci. 2012 Feb 8;32(6):2002-12. doi: 10.1523/JNEUROSCI.1144-11.2012. J Neurosci. 2012. PMID: 22323714 Free PMC article.

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