Comparison of the Mechanisms of Heme Hydroxylation by Heme Oxygenases-1 and -2: Kinetic and Cryoreduction Studies.
Davydov R, Fleischhacker AS, Bagai I, Hoffman BM, Ragsdale SW.
Davydov R, et al. Among authors: fleischhacker as.
Biochemistry. 2016 Jan 12;55(1):62-8. doi: 10.1021/acs.biochem.5b00943. Epub 2015 Dec 23.
Biochemistry. 2016.
PMID: 26652036
Free PMC article.
Unlike HO1, HO2 contains two C-terminal heme regulatory motifs (HRMs) centered at Cys265 and Cys282 that act as redox switches and, in their reduced dithiolate state, bind heme (Fleischhacker et al., Biochemistry , 2015 , 54 , 2693 - 2708 ). ...Kinetic studies revea …
Unlike HO1, HO2 contains two C-terminal heme regulatory motifs (HRMs) centered at Cys265 and Cys282 that act as redox switches and, i …