Fraser JS - Search Results

1

Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.

Dellus-Gur E, Elias M, Caselli E, Prati F, Salverda ML, de Visser JA, Fraser JS, Tawfik DS. Dellus-Gur E, et al. Among authors: fraser js. J Mol Biol. 2015 Jul 17;427(14):2396-409. doi: 10.1016/j.jmb.2015.05.011. Epub 2015 May 22. J Mol Biol. 2015. PMID: 26004540 Free PMC article.

2

E pluribus unum, no more: from one crystal, many conformations.

Woldeyes RA, Sivak DA, Fraser JS. Woldeyes RA, et al. Among authors: fraser js. Curr Opin Struct Biol. 2014 Oct;28:56-62. doi: 10.1016/j.sbi.2014.07.005. Epub 2014 Aug 9. Curr Opin Struct Biol. 2014. PMID: 25113271 Free PMC article. Review.

3

Exposing Hidden Alternative Backbone Conformations in X-ray Crystallography Using qFit.

Keedy DA, Fraser JS, van den Bedem H. Keedy DA, et al. Among authors: fraser js. PLoS Comput Biol. 2015 Oct 27;11(10):e1004507. doi: 10.1371/journal.pcbi.1004507. eCollection 2015 Oct. PLoS Comput Biol. 2015. PMID: 26506617 Free PMC article.

4

CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites.

Cimermancic P, Weinkam P, Rettenmaier TJ, Bichmann L, Keedy DA, Woldeyes RA, Schneidman-Duhovny D, Demerdash ON, Mitchell JC, Wells JA, Fraser JS, Sali A. Cimermancic P, et al. Among authors: fraser js. J Mol Biol. 2016 Feb 22;428(4):709-719. doi: 10.1016/j.jmb.2016.01.029. Epub 2016 Feb 5. J Mol Biol. 2016. PMID: 26854760 Free PMC article.

5

Rescue of conformational dynamics in enzyme catalysis by directed evolution.

Otten R, Liu L, Kenner LR, Clarkson MW, Mavor D, Tawfik DS, Kern D, Fraser JS. Otten R, et al. Among authors: fraser js. Nat Commun. 2018 Apr 3;9(1):1314. doi: 10.1038/s41467-018-03562-9. Nat Commun. 2018. PMID: 29615624 Free PMC article.

6

A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis.

Jayaraman V, Lee DJ, Elad N, Vimer S, Sharon M, Fraser JS, Tawfik DS. Jayaraman V, et al. Among authors: fraser js. Nat Chem Biol. 2022 Feb;18(2):161-170. doi: 10.1038/s41589-021-00919-y. Epub 2021 Dec 20. Nat Chem Biol. 2022. PMID: 34931064 Free PMC article.

7

Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance.

Tsai K, Stojković V, Noda-Garcia L, Young ID, Myasnikov AG, Kleinman J, Palla A, Floor SN, Frost A, Fraser JS, Tawfik DS, Fujimori DG. Tsai K, et al. Among authors: fraser js. Elife. 2022 Jan 11;11:e70017. doi: 10.7554/eLife.70017. Elife. 2022. PMID: 35015630 Free PMC article.

8

An atypical receiver domain controls the dynamic polar localization of the Myxococcus xanthus social motility protein FrzS.

Fraser JS, Merlie JP Jr, Echols N, Weisfield SR, Mignot T, Wemmer DE, Zusman DR, Alber T. Fraser JS, et al. Mol Microbiol. 2007 Jul;65(2):319-32. doi: 10.1111/j.1365-2958.2007.05785.x. Epub 2007 Jun 15. Mol Microbiol. 2007. PMID: 17573816 Free PMC article.

9

Mining electron density for functionally relevant protein polysterism in crystal structures.

Fraser JS, Jackson CJ. Fraser JS, et al. Cell Mol Life Sci. 2011 Jun;68(11):1829-41. doi: 10.1007/s00018-010-0611-4. Epub 2010 Dec 29. Cell Mol Life Sci. 2011. PMID: 21190057 Free PMC article. Review.

10

From systems to structure: bridging networks and mechanism.

Fraser JS, Gross JD, Krogan NJ. Fraser JS, et al. Mol Cell. 2013 Jan 24;49(2):222-31. doi: 10.1016/j.molcel.2013.01.003. Mol Cell. 2013. PMID: 23352243 Free PMC article. Review.

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