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The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.
Teuscher F, Lowther J, Skinner-Adams TS, Spielmann T, Dixon MW, Stack CM, Donnelly S, Mucha A, Kafarski P, Vassiliou S, Gardiner DL, Dalton JP, Trenholme KR. Teuscher F, et al. Among authors: stack cm. J Biol Chem. 2007 Oct 19;282(42):30817-26. doi: 10.1074/jbc.M704938200. Epub 2007 Aug 20. J Biol Chem. 2007. PMID: 17720817 Free article.
Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development.
Stack CM, Lowther J, Cunningham E, Donnelly S, Gardiner DL, Trenholme KR, Skinner-Adams TS, Teuscher F, Grembecka J, Mucha A, Kafarski P, Lua L, Bell A, Dalton JP. Stack CM, et al. J Biol Chem. 2007 Jan 19;282(3):2069-80. doi: 10.1074/jbc.M609251200. Epub 2006 Nov 15. J Biol Chem. 2007. PMID: 17107951 Free article.
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase.
McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL, Whisstock JC, Dalton JP. McGowan S, et al. Among authors: stack cm. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2537-42. doi: 10.1073/pnas.0807398106. Epub 2009 Feb 5. Proc Natl Acad Sci U S A. 2009. PMID: 19196988 Free PMC article.
Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials.
Skinner-Adams TS, Stack CM, Trenholme KR, Brown CL, Grembecka J, Lowther J, Mucha A, Drag M, Kafarski P, McGowan S, Whisstock JC, Gardiner DL, Dalton JP. Skinner-Adams TS, et al. Among authors: stack cm. Trends Biochem Sci. 2010 Jan;35(1):53-61. doi: 10.1016/j.tibs.2009.08.004. Epub 2009 Sep 30. Trends Biochem Sci. 2010. PMID: 19796954 Review.
Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.
McGowan S, Oellig CA, Birru WA, Caradoc-Davies TT, Stack CM, Lowther J, Skinner-Adams T, Mucha A, Kafarski P, Grembecka J, Trenholme KR, Buckle AM, Gardiner DL, Dalton JP, Whisstock JC. McGowan S, et al. Among authors: stack cm. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2449-54. doi: 10.1073/pnas.0911813107. Epub 2010 Jan 21. Proc Natl Acad Sci U S A. 2010. PMID: 20133789 Free PMC article.
53 results