MacCarthy T - Search Results

1

DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes.

Maul RW, MacCarthy T, Frank EG, Donigan KA, McLenigan MP, Yang W, Saribasak H, Huston DE, Lange SS, Woodgate R, Gearhart PJ. Maul RW, et al. Among authors: maccarthy t. J Exp Med. 2016 Aug 22;213(9):1675-83. doi: 10.1084/jem.20151227. Epub 2016 Jul 25. J Exp Med. 2016. PMID: 27455952 Free PMC article.

2

SHMTool: a webserver for comparative analysis of somatic hypermutation datasets.

Maccarthy T, Roa S, Scharff MD, Bergman A. Maccarthy T, et al. DNA Repair (Amst). 2009 Jan 1;8(1):137-41. doi: 10.1016/j.dnarep.2008.09.006. Epub 2008 Nov 8. DNA Repair (Amst). 2009. PMID: 18952008 Free PMC article.

3

AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes.

Tang C, Bagnara D, Chiorazzi N, Scharff MD, MacCarthy T. Tang C, et al. Among authors: maccarthy t. Front Immunol. 2020 Apr 30;11:788. doi: 10.3389/fimmu.2020.00788. eCollection 2020. Front Immunol. 2020. PMID: 32425948 Free PMC article.

4

Correlations in Somatic Hypermutation Between Sites in IGHV Genes Can Be Explained by Interactions Between AID and/or Polη Hotspots.

Krantsevich A, Tang C, MacCarthy T. Krantsevich A, et al. Among authors: maccarthy t. Front Immunol. 2021 Feb 2;11:618409. doi: 10.3389/fimmu.2020.618409. eCollection 2020. Front Immunol. 2021. PMID: 33603748 Free PMC article.

5

Characterization of DNA G-Quadruplex Structures in Human Immunoglobulin Heavy Variable (IGHV) Genes.

Tang C, MacCarthy T. Tang C, et al. Among authors: maccarthy t. Front Immunol. 2021 May 10;12:671944. doi: 10.3389/fimmu.2021.671944. eCollection 2021. Front Immunol. 2021. PMID: 34040612 Free PMC article.

6

Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes.

Duan Z, Baughn LB, Wang X, Zhang Y, Gupta V, MacCarthy T, Scharff MD, Yu G. Duan Z, et al. Among authors: maccarthy t. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2104013118. doi: 10.1073/pnas.2104013118. Proc Natl Acad Sci U S A. 2021. PMID: 34253616 Free PMC article.

7

A Bayesian model based computational analysis of the relationship between bisulfite accessible single-stranded DNA in chromatin and somatic hypermutation of immunoglobulin genes.

Yu G, Wu Y, Duan Z, Tang C, Xing H, Scharff MD, MacCarthy T. Yu G, et al. Among authors: maccarthy t. PLoS Comput Biol. 2021 Sep 7;17(9):e1009323. doi: 10.1371/journal.pcbi.1009323. eCollection 2021 Sep. PLoS Comput Biol. 2021. PMID: 34491985 Free PMC article.

8

The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions.

Yu G, Zhang Y, Gupta V, Zhang J, MacCarthy T, Duan Z, Scharff MD. Yu G, et al. Among authors: maccarthy t. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2114743118. doi: 10.1073/pnas.2114743118. Proc Natl Acad Sci U S A. 2021. PMID: 34873043 Free PMC article.

9

Interpretable deep learning reveals the role of an E-box motif in suppressing somatic hypermutation of AGCT motifs within human immunoglobulin variable regions.

Tambe A, MacCarthy T, Pavri R. Tambe A, et al. Among authors: maccarthy t. Front Immunol. 2024 May 28;15:1407470. doi: 10.3389/fimmu.2024.1407470. eCollection 2024. Front Immunol. 2024. PMID: 38863710 Free PMC article.

10

Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.

Roa S, Avdievich E, Peled JU, Maccarthy T, Werling U, Kuang FL, Kan R, Zhao C, Bergman A, Cohen PE, Edelmann W, Scharff MD. Roa S, et al. Among authors: maccarthy t. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16248-53. doi: 10.1073/pnas.0808182105. Epub 2008 Oct 14. Proc Natl Acad Sci U S A. 2008. PMID: 18854411 Free PMC article.

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