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TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL.
Thébault S, Agez M, Chi X, Stojko J, Cura V, Telerman SB, Maillet L, Gautier F, Billas-Massobrio I, Birck C, Troffer-Charlier N, Karafin T, Honoré J, Senff-Ribeiro A, Montessuit S, Johnson CM, Juin P, Cianférani S, Martinou JC, Andrews DW, Amson R, Telerman A, Cavarelli J. Thébault S, et al. Sci Rep. 2016 Jan 27;6:19725. doi: 10.1038/srep19725. Sci Rep. 2016. PMID: 26813996 Free PMC article.
TCTP as a therapeutic target in melanoma treatment.
Boia-Ferreira M, Basílio AB, Hamasaki AE, Matsubara FH, Appel MH, Da Costa CRV, Amson R, Telerman A, Chaim OM, Veiga SS, Senff-Ribeiro A. Boia-Ferreira M, et al. Br J Cancer. 2017 Aug 22;117(5):656-665. doi: 10.1038/bjc.2017.230. Epub 2017 Jul 27. Br J Cancer. 2017. PMID: 28751755 Free PMC article.
Molecular cloning, heterologous expression and functional characterization of a novel translationally-controlled tumor protein (TCTP) family member from Loxosceles intermedia (brown spider) venom.
Sade YB, Bóia-Ferreira M, Gremski LH, da Silveira RB, Gremski W, Senff-Ribeiro A, Chaim OM, Veiga SS. Sade YB, et al. Int J Biochem Cell Biol. 2012 Jan;44(1):170-7. doi: 10.1016/j.biocel.2011.10.013. Epub 2011 Oct 29. Int J Biochem Cell Biol. 2012. PMID: 22051631 Free article.
Biotechnological applications of brown spider (Loxosceles genus) venom toxins.
Senff-Ribeiro A, Henrique da Silva P, Chaim OM, Gremski LH, Paludo KS, Bertoni da Silveira R, Gremski W, Mangili OC, Veiga SS. Senff-Ribeiro A, et al. Biotechnol Adv. 2008 May-Jun;26(3):210-8. doi: 10.1016/j.biotechadv.2007.12.003. Epub 2007 Dec 23. Biotechnol Adv. 2008. PMID: 18207690 Review.
56 results