Kidney transplant recipients carrying the CYP3A4*22 allelic variant have reduced tacrolimus clearance and often reach supratherapeutic tacrolimus concentrations.
Pallet N, Jannot AS, El Bahri M, Etienne I, Buchler M, de Ligny BH, Choukroun G, Colosio C, Thierry A, Vigneau C, Moulin B, Le Meur Y, Heng AE, Subra JF, Legendre C, Beaune P, Alberti C, Loriot MA, Thervet E.
Pallet N, et al. Among authors: jannot as.
Am J Transplant. 2015 Mar;15(3):800-5. doi: 10.1111/ajt.13059. Epub 2015 Jan 14.
Am J Transplant. 2015.
PMID: 25588704
Free article.