Hruby VJ - Search Results

1

Importance of the C-terminal alpha-helical structure for glucagon's biological activity.

Krstenansky JL, Zechel C, Trivedi D, Hruby VJ. Krstenansky JL, et al. Among authors: hruby vj. Int J Pept Protein Res. 1988 Dec;32(6):468-75. doi: 10.1111/j.1399-3011.1988.tb01377.x. Int J Pept Protein Res. 1988. PMID: 2854536

2

Synthetic glucagon antagonists and partial agonists.

Zechel C, Trivedi D, Hruby VJ. Zechel C, et al. Among authors: hruby vj. Int J Pept Protein Res. 1991 Aug;38(2):131-8. doi: 10.1111/j.1399-3011.1991.tb01420.x. Int J Pept Protein Res. 1991. PMID: 1664420

3

Synthetic linear and cyclic glucagon antagonists.

Dharanipragada R, Trivedi D, Bannister A, Siegel M, Tourwe D, Mollova N, Schram K, Hruby VJ. Dharanipragada R, et al. Among authors: hruby vj. Int J Pept Protein Res. 1993 Jul;42(1):68-77. doi: 10.1111/j.1399-3011.1993.tb00352.x. Int J Pept Protein Res. 1993. PMID: 8396562

4

New glucagon analogues with conformational restrictions and altered amphiphilicity: effects on binding, adenylate cyclase and glycogenolytic activities.

Hruby VJ, Gysin B, Trivedi D, Johnson DG. Hruby VJ, et al. Life Sci. 1993;52(10):845-55. doi: 10.1016/0024-3205(93)90513-3. Life Sci. 1993. PMID: 8445980

5

Structure-activity studies of hydrophobic amino acid replacements at positions 9, 11 and 16 of glucagon.

Sturm NS, Hutzler AM, David CS, Azizeh BY, Trivedi D, Hruby VJ. Sturm NS, et al. Among authors: hruby vj. J Pept Res. 1997 Apr;49(4):293-9. doi: 10.1111/j.1399-3011.1997.tb01129.x. J Pept Res. 1997. PMID: 9176812

6

Pure glucagon antagonists: biological activities and cAMP accumulation using phosphodiesterase inhibitors.

Azizeh BY, Van Tine BA, Trivedi D, Hruby VJ. Azizeh BY, et al. Among authors: hruby vj. Peptides. 1997;18(5):633-41. doi: 10.1016/s0196-9781(97)00131-9. Peptides. 1997. PMID: 9213355

7

The role of phenylalanine at position 6 in glucagon's mechanism of biological action: multiple replacement analogues of glucagon.

Azizeh BY, Ahn JM, Caspari R, Shenderovich MD, Trivedi D, Hruby VJ. Azizeh BY, et al. Among authors: hruby vj. J Med Chem. 1997 Aug 1;40(16):2555-62. doi: 10.1021/jm960800d. J Med Chem. 1997. PMID: 9258362

8

Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity.

Sturm NS, Lin Y, Burley SK, Krstenansky JL, Ahn JM, Azizeh BY, Trivedi D, Hruby VJ. Sturm NS, et al. Among authors: hruby vj. J Med Chem. 1998 Jul 16;41(15):2693-700. doi: 10.1021/jm980084a. J Med Chem. 1998. PMID: 9667960

9

Development of potent truncated glucagon antagonists.

Ahn JM, Medeiros M, Trivedi D, Hruby VJ. Ahn JM, et al. Among authors: hruby vj. J Med Chem. 2001 Apr 26;44(9):1372-9. doi: 10.1021/jm000453e. J Med Chem. 2001. PMID: 11311060

10

Development of potent glucagon antagonists: structure-activity relationship study of glycine at position 4.

Ahn JM, Medeiros M, Trivedi D, Hruby VJ. Ahn JM, et al. Among authors: hruby vj. J Pept Res. 2001 Aug;58(2):151-8. doi: 10.1034/j.1399-3011.2001.00880.x. J Pept Res. 2001. PMID: 11532074

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