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A novel secreted metalloprotease (CD2830) from Clostridium difficile cleaves specific proline sequences in LPXTG cell surface proteins.
Hensbergen PJ, Klychnikov OI, Bakker D, van Winden VJ, Ras N, Kemp AC, Cordfunke RA, Dragan I, Deelder AM, Kuijper EJ, Corver J, Drijfhout JW, van Leeuwen HC. Hensbergen PJ, et al. Among authors: van winden vj, van leeuwen hc. Mol Cell Proteomics. 2014 May;13(5):1231-44. doi: 10.1074/mcp.M113.034728. Epub 2014 Mar 12. Mol Cell Proteomics. 2014. PMID: 24623589 Free PMC article.
Clostridium difficile secreted Pro-Pro endopeptidase PPEP-1 (ZMP1/CD2830) modulates adhesion through cleavage of the collagen binding protein CD2831.
Hensbergen PJ, Klychnikov OI, Bakker D, Dragan I, Kelly ML, Minton NP, Corver J, Kuijper EJ, Drijfhout JW, van Leeuwen HC. Hensbergen PJ, et al. Among authors: van leeuwen hc. FEBS Lett. 2015 Dec 21;589(24 Pt B):3952-8. doi: 10.1016/j.febslet.2015.10.027. Epub 2015 Oct 29. FEBS Lett. 2015. PMID: 26522134 Free article.
Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP family.
Klychnikov OI, Shamorkina TM, Weeks SD, van Leeuwen HC, Corver J, Drijfhout JW, van Veelen PA, Sluchanko NN, Strelkov SV, Hensbergen PJ. Klychnikov OI, et al. Among authors: van leeuwen hc, van veelen pa. J Biol Chem. 2018 Jul 13;293(28):11154-11165. doi: 10.1074/jbc.RA118.003244. Epub 2018 May 23. J Biol Chem. 2018. PMID: 29794027 Free PMC article.
Genetic markers for Clostridium difficile lineages linked to hypervirulence.
Knetsch CW, Hensgens MPM, Harmanus C, van der Bijl MW, Savelkoul PHM, Kuijper EJ, Corver J, van Leeuwen HC. Knetsch CW, et al. Among authors: van der bijl mw, van leeuwen hc. Microbiology (Reading). 2011 Nov;157(Pt 11):3113-3123. doi: 10.1099/mic.0.051953-0. Epub 2011 Aug 26. Microbiology (Reading). 2011. PMID: 21873406 Free article.
58 results