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A phase 1 trial of MSP2-C1, a blood-stage malaria vaccine containing 2 isoforms of MSP2 formulated with Montanide® ISA 720.
McCarthy JS, Marjason J, Elliott S, Fahey P, Bang G, Malkin E, Tierney E, Aked-Hurditch H, Adda C, Cross N, Richards JS, Fowkes FJ, Boyle MJ, Long C, Druilhe P, Beeson JG, Anders RF. McCarthy JS, et al. PLoS One. 2011;6(9):e24413. doi: 10.1371/journal.pone.0024413. Epub 2011 Sep 19. PLoS One. 2011. PMID: 21949716 Free PMC article. Clinical Trial.
Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria.
Boyle MJ, Reiling L, Feng G, Langer C, Osier FH, Aspeling-Jones H, Cheng YS, Stubbs J, Tetteh KK, Conway DJ, McCarthy JS, Muller I, Marsh K, Anders RF, Beeson JG. Boyle MJ, et al. Among authors: mccarthy js. Immunity. 2015 Mar 17;42(3):580-90. doi: 10.1016/j.immuni.2015.02.012. Immunity. 2015. PMID: 25786180 Free PMC article. Clinical Trial.
Profoundly Reduced CD1c+ Myeloid Dendritic Cell HLA-DR and CD86 Expression and Increased Tumor Necrosis Factor Production in Experimental Human Blood-Stage Malaria Infection.
Loughland JR, Minigo G, Burel J, Tipping PE, Piera KA, Amante FH, Engwerda CR, Good MF, Doolan DL, Anstey NM, McCarthy JS, Woodberry T. Loughland JR, et al. Among authors: mccarthy js. Infect Immun. 2016 Apr 22;84(5):1403-1412. doi: 10.1128/IAI.01522-15. Print 2016 May. Infect Immun. 2016. PMID: 26902728 Free PMC article.
Infectivity of Plasmodium falciparum in Malaria-Naive Individuals Is Related to Knob Expression and Cytoadherence of the Parasite.
Stanisic DI, Gerrard J, Fink J, Griffin PM, Liu XQ, Sundac L, Sekuloski S, Rodriguez IB, Pingnet J, Yang Y, Zhou Y, Trenholme KR, Wang CY, Hackett H, Chan JA, Langer C, Hanssen E, Hoffman SL, Beeson JG, McCarthy JS, Good MF. Stanisic DI, et al. Among authors: mccarthy js. Infect Immun. 2016 Aug 19;84(9):2689-96. doi: 10.1128/IAI.00414-16. Print 2016 Sep. Infect Immun. 2016. PMID: 27382019 Free PMC article.
Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection.
Montes de Oca M, Kumar R, Rivera FL, Amante FH, Sheel M, Faleiro RJ, Bunn PT, Best SE, Beattie L, Ng SS, Edwards CL, Boyle GM, Price RN, Anstey NM, Loughland JR, Burel J, Doolan DL, Haque A, McCarthy JS, Engwerda CR. Montes de Oca M, et al. Among authors: mccarthy js. Cell Rep. 2016 Oct 4;17(2):399-412. doi: 10.1016/j.celrep.2016.09.015. Cell Rep. 2016. PMID: 27705789 Free PMC article.
Early Immune Regulatory Changes in a Primary Controlled Human Plasmodium vivax Infection: CD1c+ Myeloid Dendritic Cell Maturation Arrest, Induction of the Kynurenine Pathway, and Regulatory T Cell Activation.
Woodberry T, Loughland JR, Minigo G, Burel JG, Amante FH, Piera KA, McNeil Y, Yeo TW, Good MF, Doolan DL, Engwerda CR, McCarthy JS, Anstey NM. Woodberry T, et al. Among authors: mccarthy js. Infect Immun. 2017 May 23;85(6):e00986-16. doi: 10.1128/IAI.00986-16. Print 2017 Jun. Infect Immun. 2017. PMID: 28320838 Free PMC article.
322 results