Bus JS - Search Results

1

Based on an analysis of mode of action, styrene-induced mouse lung tumors are not a human cancer concern.

Cruzan G, Bus JS, Andersen ME, Carlson GP, Banton MI, Sarang SS, Waites R. Cruzan G, et al. Regul Toxicol Pharmacol. 2018 Jun;95:17-28. doi: 10.1016/j.yrtph.2018.02.010. Epub 2018 Feb 26. Regul Toxicol Pharmacol. 2018. PMID: 29496518 Free article.

2

CYP2F2-generated metabolites, not styrene oxide, are a key event mediating the mode of action of styrene-induced mouse lung tumors.

Cruzan G, Bus J, Hotchkiss J, Harkema J, Banton M, Sarang S. Cruzan G, et al. Regul Toxicol Pharmacol. 2012 Feb;62(1):214-20. doi: 10.1016/j.yrtph.2011.10.007. Epub 2011 Oct 21. Regul Toxicol Pharmacol. 2012. PMID: 22041433 Free article.

3

Studies of styrene, styrene oxide and 4-hydroxystyrene toxicity in CYP2F2 knockout and CYP2F1 humanized mice support lack of human relevance for mouse lung tumors.

Cruzan G, Bus J, Hotchkiss J, Sura R, Moore C, Yost G, Banton M, Sarang S. Cruzan G, et al. Regul Toxicol Pharmacol. 2013 Jun;66(1):24-9. doi: 10.1016/j.yrtph.2013.02.008. Epub 2013 Feb 27. Regul Toxicol Pharmacol. 2013. PMID: 23454103

4

Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action.

Cruzan G, Bus J, Banton M, Gingell R, Carlson G. Cruzan G, et al. Regul Toxicol Pharmacol. 2009 Nov;55(2):205-18. doi: 10.1016/j.yrtph.2009.07.002. Epub 2009 Jul 7. Regul Toxicol Pharmacol. 2009. PMID: 19589367 Review.

5

Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures.

Andersen ME, Cruzan G, Black MB, Pendse SN, Dodd D, Bus JS, Sarang SS, Banton MI, Waites R, McMullen PD. Andersen ME, et al. Toxicol Appl Pharmacol. 2017 Nov 15;335:28-40. doi: 10.1016/j.taap.2017.09.015. Epub 2017 Sep 23. Toxicol Appl Pharmacol. 2017. PMID: 28951217 Free article.

6

Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance.

Cruzan G, Bus JS, Banton MI, Sarang SS, Waites R, Layko DB, Raymond J, Dodd D, Andersen ME. Cruzan G, et al. Toxicol Sci. 2017 Oct 1;159(2):413-421. doi: 10.1093/toxsci/kfx141. Toxicol Sci. 2017. PMID: 28962520 Free PMC article.

7

Andersen ME, Cruzan G, Black MB, Pendse SN, Dodd DE, Bus JS, Sarang SS, Banton MI, Waites R, Layko DB, McMullen PD. Andersen ME, et al. Regul Toxicol Pharmacol. 2018 Jul;96:153-166. doi: 10.1016/j.yrtph.2018.05.011. Epub 2018 May 17. Regul Toxicol Pharmacol. 2018. PMID: 29777725 Free article.

8

Consideration of Styrene Transcriptomic Data Informs Mouse Lung Cyp2F2-Mediated Adverse Outcome Pathway.

Andersen ME, Bus JS. Andersen ME, et al. Toxicol Sci. 2020 May 1;175(1):3-4. doi: 10.1093/toxsci/kfaa020. Toxicol Sci. 2020. PMID: 32049351 No abstract available.

9

Evaluation of potential health effects associated with occupational and environmental exposure to styrene - an update.

Banton MI, Bus JS, Collins JJ, Delzell E, Gelbke HP, Kester JE, Moore MM, Waites R, Sarang SS. Banton MI, et al. J Toxicol Environ Health B Crit Rev. 2019;22(1-4):1-130. doi: 10.1080/10937404.2019.1633718. Epub 2019 Jul 8. J Toxicol Environ Health B Crit Rev. 2019. PMID: 31284836 Free article. Review.

10

Considerations for refining the risk assessment process for formaldehyde: Results from an interdisciplinary workshop.

Andersen ME, Gentry PR, Swenberg JA, Mundt KA, White KW, Thompson C, Bus J, Sherman JH, Greim H, Bolt H, Marsh GM, Checkoway H, Coggon D, Clewell HJ 3rd. Andersen ME, et al. Regul Toxicol Pharmacol. 2019 Aug;106:210-223. doi: 10.1016/j.yrtph.2019.04.015. Epub 2019 May 3. Regul Toxicol Pharmacol. 2019. PMID: 31059732 Free article. Review.

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