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Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer.
Al-Hilal TA, Chrysovergi MA, Grasberger PE, Liu F, Auernheimer V, Zhou Y, Xiao Z, Leon-Duque MA, Santos A, Islam T, Ligorio M, Sicard D, Probst CK, Vrbanac V, Reddi TS, Vincent L, Happe C, Chaum E, Yates CR, Daneshvar K, Mullen AC, Ting D, White ES, Kalluri R, Woo CM, Puré E, Goldmann WH, Alonso JL, Tager AM, Engler AJ, Tschumperlin DJ, Lagares D. Al-Hilal TA, et al. Among authors: probst ck. Nat Cell Biol. 2025 Sep;27(9):1543-1554. doi: 10.1038/s41556-025-01697-8. Epub 2025 Sep 9. Nat Cell Biol. 2025. PMID: 40925952 Free PMC article.
Myofibroblast-specific inhibition of the Rho kinase-MRTF-SRF pathway using nanotechnology for the prevention of pulmonary fibrosis.
Knipe RS, Nurunnabi M, Probst CK, Spinney JJ, Abe E, Bose RJC, Ha K, Logue A, Nguyen T, Servis R, Drummond M, Haring A, Brazee PL, Medoff BD, McCarthy JR. Knipe RS, et al. Among authors: probst ck. Am J Physiol Lung Cell Mol Physiol. 2023 Feb 1;324(2):L190-L198. doi: 10.1152/ajplung.00086.2022. Epub 2023 Jan 10. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 36625494 Free PMC article.
Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.
Axelsson Raja A, Wakimoto H, DeLaughter DM, Reichart D, Gorham J, Conner DA, Lun M, Probst CK, Sakai N, Knipe RS, Montesi SB, Shea B, Adam LP, Leinwand LA, Wan W, Choi ES, Lindberg EL, Patone G, Noseda M, Hübner N, Seidman CE, Tager AM, Seidman JG, Ho CY. Axelsson Raja A, et al. Among authors: probst ck. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2204174119. doi: 10.1073/pnas.2204174119. Epub 2022 Jul 5. Proc Natl Acad Sci U S A. 2022. PMID: 35787042 Free PMC article.
A tissue-bioengineering strategy for modeling rare human kidney diseases in vivo.
Hernandez JOR, Wang X, Vazquez-Segoviano M, Lopez-Marfil M, Sobral-Reyes MF, Moran-Horowich A, Sundberg M, Lopez-Cantu DO, Probst CK, Ruiz-Esparza GU, Giannikou K, Abdi R, Henske EP, Kwiatkowski DJ, Sahin M, Lemos DR. Hernandez JOR, et al. Among authors: probst ck. Nat Commun. 2021 Nov 11;12(1):6496. doi: 10.1038/s41467-021-26596-y. Nat Commun. 2021. PMID: 34764250 Free PMC article.
Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis.
Knipe RS, Spinney JJ, Abe EA, Probst CK, Franklin A, Logue A, Giacona F, Drummond M, Griffith J, Brazee PL, Hariri LP, Montesi SB, Black KE, Hla T, Kuo A, Cartier A, Engelbrecht E, Christoffersen C, Shea BS, Tager AM, Medoff BD. Knipe RS, et al. Among authors: probst ck. Am J Respir Cell Mol Biol. 2022 Jan;66(1):38-52. doi: 10.1165/rcmb.2020-0408OC. Am J Respir Cell Mol Biol. 2022. PMID: 34343038 Free PMC article.
Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex.
Kovalenko A, Sanin A, Kosmas K, Zhang L, Wang J, Akl EW, Giannikou K, Probst CK, Hougard TR, Rue RW, Krymskaya VP, Asara JM, Lam HC, Kwiatkowski DJ, Henske EP, Filippakis H. Kovalenko A, et al. Among authors: probst ck. Cancer Res. 2021 Apr 15;81(8):2086-2100. doi: 10.1158/0008-5472.CAN-20-2218. Epub 2021 Feb 16. Cancer Res. 2021. PMID: 33593821 Free PMC article.
Vascular permeability in the fibrotic lung.
Probst CK, Montesi SB, Medoff BD, Shea BS, Knipe RS. Probst CK, et al. Eur Respir J. 2020 Jul 16;56(1):1900100. doi: 10.1183/13993003.00100-2019. Print 2020 Jul. Eur Respir J. 2020. PMID: 32265308 Free PMC article.
24 results