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Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1Glu280Ala mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial.
Tariot PN, Lopera FS, Ríos-Romenets S, Sink KM, Giraldo-Chica M, Acosta-Baena N, Villegas G, Espinosa A, Castaño ML, Muñoz C, Ospina P, Bocanegra Y, Tirado V, Henao E, Cardona E, Luna E, Lopez H, Sánchez G, Collazos MM, Alvarez S, Aguillón D, Hu N, Clayton D, Bittner T, Schneider A, Dolton M, Poon V, Nguyen J, Thomas RG, Schneider LS, Chen K, Su Y, Alexander RC, Quiroz YT, Cai Y, Xu YR, Ostaszewski B, Selkoe DJ, Ashton NJ, Denkinger MN, Jakimovich LJ, Doody RS, Langbaum JB, Reiman EM. Tariot PN, et al. Among authors: rios romenets s. Lancet Neurol. 2026 Feb;25(2):147-159. doi: 10.1016/S1474-4422(25)00426-0. Lancet Neurol. 2026. PMID: 41579901 Free article. Clinical Trial.
Plasma p-tau231 in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional and longitudinal cohort study.
Malotaux V, Ashton NJ, Öhrfelt A, Chen Y, Su Y, Garcia-Ospina G, Guzman-Martínez C, Villegas-Lanau A, Gómez-Ramirez J, Giraldo-Chica M, Aguillon D, Tirado V, Baena A, Munoz C, Acosta-Baena N, Pruzin JJ, Ghisays V, Rios-Romenets S, Vila-Castelar C, Martínez JE, Giudicessi A, Tariot PN, Zetterberg H, Blennow K, Reiman EM, Quiroz YT. Malotaux V, et al. Among authors: rios romenets s. Alzheimers Dement. 2025 Jul;21(7):e70421. doi: 10.1002/alz.70421. Alzheimers Dement. 2025. PMID: 40588692 Free PMC article.
Impact of APOE ε4 and ε2 on plasma neurofilament light chain and cognition in autosomal dominant Alzheimer's disease.
Langella S, Bonta K, Chen Y, Su Y, Vasquez D, Aguillon D, Acosta-Baena N, Baena AY, Garcia-Ospina G, Giraldo-Chica M, Tirado V, Muñoz C, Ríos-Romenets S, Guzman-Martínez C, Pruzin JJ, Ghisays V, Arboleda-Velasquez JF, Kosik KS, Tariot PN, Reiman EM, Lopera F, Quiroz YT. Langella S, et al. Among authors: rios romenets s. Alzheimers Res Ther. 2024 Oct 1;16(1):208. doi: 10.1186/s13195-024-01572-y. Alzheimers Res Ther. 2024. PMID: 39354618 Free PMC article.
Psychological Status of the Participants in Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Colombia.
Ramos C, Madrigal C, Aguirre-Acevedo DC, Giraldo-Chica M, Acosta-Baena N, Aponte C, Aguillón D, Gómez M, Espinosa A, Madrigal L, Uribe C, Saldarriaga A, Alzate D, Ruiz A, Andrade A, Lopez H, Langbaum JB, Sink KM, Reiman EM, Tariot PN, Ríos-Romenets S, Lopera F. Ramos C, et al. Among authors: rios romenets s. J Alzheimers Dis. 2023;95(3):1091-1106. doi: 10.3233/JAD-220941. J Alzheimers Dis. 2023. PMID: 37638430 Free PMC article.
Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer's disease.
Langella S, Barksdale NG, Vasquez D, Aguillon D, Chen Y, Su Y, Acosta-Baena N, Acosta-Uribe J, Baena AY, Garcia-Ospina G, Giraldo-Chica M, Tirado V, Muñoz C, Ríos-Romenets S, Guzman-Martínez C, Oliveira G, Yang HS, Vila-Castelar C, Pruzin JJ, Ghisays V, Arboleda-Velasquez JF, Kosik KS, Reiman EM, Lopera F, Quiroz YT. Langella S, et al. Among authors: rios romenets s. Nat Commun. 2023 Aug 23;14(1):5120. doi: 10.1038/s41467-023-40775-z. Nat Commun. 2023. PMID: 37612284 Free PMC article.
Sex differences in blood biomarkers and cognitive performance in individuals with autosomal dominant Alzheimer's disease.
Vila-Castelar C, Chen Y, Langella S, Lopera F, Zetterberg H, Hansson O, Dage JL, Janelidzde S, Su Y, Chen K, Pluim McDowell C, Martinez JE, Ramirez-Gomez L, Garcia G, Aguillon D, Baena A, Giraldo-Chica M, Protas HD, Ghisays V, Rios-Romenets S, Tariot PN, Blennow K, Reiman EM, Quiroz YT. Vila-Castelar C, et al. Among authors: rios romenets s. Alzheimers Dement. 2023 Sep;19(9):4127-4138. doi: 10.1002/alz.13314. Epub 2023 Jun 6. Alzheimers Dement. 2023. PMID: 37279390 Free PMC article.
A public resource of baseline data from the Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial.
Reiman EM, Pruzin JJ, Rios-Romenets S, Brown C, Giraldo M, Acosta-Baena N, Tobon C, Hu N, Chen Y, Ghisays V, Enos J, Goradia DD, Lee W, Luo J, Malek-Ahmadi M, Protas H, Thomas RG, Chen K, Su Y, Boker C, Mastroeni D, Alvarez S, Quiroz YT, Langbaum JB, Sink KM, Lopera F, Tariot PN; API ADAD Colombia Trial Group. Reiman EM, et al. Among authors: rios romenets s. Alzheimers Dement. 2023 May;19(5):1938-1946. doi: 10.1002/alz.12843. Epub 2022 Nov 14. Alzheimers Dement. 2023. PMID: 36373344 Free PMC article.
Sex differences in cognitive resilience in preclinical autosomal-dominant Alzheimer's disease carriers and non-carriers: Baseline findings from the API ADAD Colombia Trial.
Vila-Castelar C, Tariot PN, Sink KM, Clayton D, Langbaum JB, Thomas RG, Chen Y, Su Y, Chen K, Hu N, Giraldo-Chica M, Tobón C, Acosta-Baena N, Luna E, Londoño M, Ospina P, Tirado V, Muñoz C, Henao E, Bocanegra Y, Alvarez S, Rios-Romenets S, Ghisays V, Goradia D, Lee W, Luo J, Malek-Ahmadi MH, Protas HD, Lopera F, Reiman EM, Quiroz YT; API ADAD Colombia Trial Group. Vila-Castelar C, et al. Among authors: rios romenets s. Alzheimers Dement. 2022 Nov;18(11):2272-2282. doi: 10.1002/alz.12552. Epub 2022 Feb 1. Alzheimers Dement. 2022. PMID: 35103388 Free PMC article. Clinical Trial.
PET evidence of preclinical cerebellar amyloid plaque deposition in autosomal dominant Alzheimer's disease-causing Presenilin-1 E280A mutation carriers.
Ghisays V, Lopera F, Goradia DD, Protas HD, Malek-Ahmadi MH, Chen Y, Devadas V, Luo J, Lee W, Baena A, Bocanegra Y, Guzmán-Vélez E, Pardilla-Delgado E, Vila-Castelar C, Fox-Fuller JT, Hu N, Clayton D, Thomas RG, Alvarez S, Espinosa A, Acosta-Baena N, Giraldo MM, Rios-Romenets S, Langbaum JB, Chen K, Su Y, Tariot PN, Quiroz YT, Reiman EM; API ADAD Colombia Trial Group. Ghisays V, et al. Among authors: rios romenets s. Neuroimage Clin. 2021;31:102749. doi: 10.1016/j.nicl.2021.102749. Epub 2021 Jul 4. Neuroimage Clin. 2021. PMID: 34252876 Free PMC article.
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