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Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway.
Gupta SC, Francis SK, Nair MS, Mo YY, Aggarwal BB. Gupta SC, et al. J Biol Chem. 2013 Nov 8;288(45):32343-32356. doi: 10.1074/jbc.M113.455188. Epub 2013 Sep 27. J Biol Chem. 2013. PMID: 24078627 Free PMC article.
Targeting IκappaB kinases for cancer therapy.
Awasthee N, Rai V, Chava S, Nallasamy P, Kunnumakkara AB, Bishayee A, Chauhan SC, Challagundla KB, Gupta SC. Awasthee N, et al. Among authors: gupta sc. Semin Cancer Biol. 2019 Jun;56:12-24. doi: 10.1016/j.semcancer.2018.02.007. Epub 2018 Feb 24. Semin Cancer Biol. 2019. PMID: 29486318 Free PMC article. Review.
Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents.
Gupta SC, Kannappan R, Kim J, Rahman GM, Francis SK, Raveendran R, Nair MS, Das J, Aggarwal BB. Gupta SC, et al. Mol Pharmacol. 2011 Nov;80(5):769-81. doi: 10.1124/mol.111.073122. Epub 2011 Jul 27. Mol Pharmacol. 2011. PMID: 21795584 Free PMC article.
PD-L1, inflammation, non-coding RNAs, and neuroblastoma: Immuno-oncology perspective.
Nallasamy P, Chava S, Verma SS, Mishra S, Gorantla S, Coulter DW, Byrareddy SN, Batra SK, Gupta SC, Challagundla KB. Nallasamy P, et al. Among authors: gupta sc. Semin Cancer Biol. 2018 Oct;52(Pt 2):53-65. doi: 10.1016/j.semcancer.2017.11.009. Epub 2017 Nov 28. Semin Cancer Biol. 2018. PMID: 29196189 Free PMC article. Review.
707 results