Lum L - Search Results

1

Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9.

Zhang LS, Kang X, Lu J, Zhang Y, Wu X, Wu G, Zheng J, Tuladhar R, Shi H, Wang Q, Morlock L, Yao H, Huang LJ, Maire P, Kim J, Williams N, Xu J, Chen C, Zhang CC, Lum L. Zhang LS, et al. Among authors: lum l. EBioMedicine. 2019 Jan;39:145-158. doi: 10.1016/j.ebiom.2018.11.039. Epub 2018 Dec 6. EBioMedicine. 2019. PMID: 30528456 Free PMC article.

2

Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine.

Lum L, Chen C. Lum L, et al. Curr Med Chem. 2015;22(35):4091-103. doi: 10.2174/0929867322666150827094015. Curr Med Chem. 2015. PMID: 26310918 Free PMC article. Review.

3

Chemical Modulation of WNT Signaling in Cancer.

Zhang LS, Lum L. Zhang LS, et al. Among authors: lum l. Prog Mol Biol Transl Sci. 2018 Jan;153:245-269. doi: 10.1016/bs.pmbts.2017.11.008. Epub 2018 Jan 8. Prog Mol Biol Transl Sci. 2018. PMID: 29389519 Review.

4

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine.

Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L. Dodge ME, et al. Among authors: lum l. J Biol Chem. 2012 Jun 29;287(27):23246-54. doi: 10.1074/jbc.M112.372029. Epub 2012 May 15. J Biol Chem. 2012. PMID: 22593577 Free PMC article.

5

The development of highly potent inhibitors for porcupine.

Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H, Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C. Wang X, et al. Among authors: lum l. J Med Chem. 2013 Mar 28;56(6):2700-4. doi: 10.1021/jm400159c. Epub 2013 Mar 19. J Med Chem. 2013. PMID: 23477365 Free PMC article.

6

Fatty acyl donor selectivity in membrane bound O-acyltransferases and communal cell fate decision-making.

Tuladhar R, Lum L. Tuladhar R, et al. Among authors: lum l. Biochem Soc Trans. 2015 Apr;43(2):235-9. doi: 10.1042/BST20140282. Biochem Soc Trans. 2015. PMID: 25849923 Free PMC article. Review.

7

Delivery of the Porcupine Inhibitor WNT974 in Mice.

Zhang LS, Lum L. Zhang LS, et al. Among authors: lum l. Methods Mol Biol. 2016;1481:111-7. doi: 10.1007/978-1-4939-6393-5_12. Methods Mol Biol. 2016. PMID: 27590157 Free PMC article.

8

Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.

Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L. Moon J, et al. Among authors: lum l. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654. doi: 10.1073/pnas.1621346114. Epub 2017 Jan 31. Proc Natl Acad Sci U S A. 2017. PMID: 28143939 Free PMC article.

9

Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN).

Tuladhar R, Yarravarapu N, Ma Y, Zhang C, Herbert J, Kim J, Chen C, Lum L. Tuladhar R, et al. Among authors: lum l. J Biol Chem. 2019 Apr 19;294(16):6273-6282. doi: 10.1074/jbc.RA118.007268. Epub 2019 Feb 8. J Biol Chem. 2019. PMID: 30737280 Free PMC article.

10

The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.

Fan CW, Chen B, Franco I, Lu J, Shi H, Wei S, Wang C, Wu X, Tang W, Roth MG, Williams NS, Hirsch E, Chen C, Lum L. Fan CW, et al. Among authors: lum l. Chem Biol. 2014 Dec 18;21(12):1680-9. doi: 10.1016/j.chembiol.2014.10.013. Epub 2014 Dec 4. Chem Biol. 2014. PMID: 25484239 Free PMC article.

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