Cohn R - Search Results

1

A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations.

Cohn R, Thakar K, Lowe A, Ladha FA, Pettinato AM, Romano R, Meredith E, Chen YS, Atamanuk K, Huey BD, Hinson JT. Cohn R, et al. Stem Cell Reports. 2019 Jan 8;12(1):71-83. doi: 10.1016/j.stemcr.2018.11.015. Epub 2018 Dec 13. Stem Cell Reports. 2019. PMID: 30554920 Free PMC article.

2

Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human TNNT2 Variants.

Pettinato AM, Ladha FA, Mellert DJ, Legere N, Cohn R, Romano R, Thakar K, Chen YS, Hinson JT. Pettinato AM, et al. Among authors: cohn r. Circulation. 2020 Dec 8;142(23):2262-2275. doi: 10.1161/CIRCULATIONAHA.120.047999. Epub 2020 Oct 7. Circulation. 2020. PMID: 33025817 Free PMC article.

3

Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment.

Pettinato AM, Yoo D, VanOudenhove J, Chen YS, Cohn R, Ladha FA, Yang X, Thakar K, Romano R, Legere N, Meredith E, Robson P, Regnier M, Cotney JL, Murry CE, Hinson JT. Pettinato AM, et al. Among authors: cohn r. Cell Rep. 2021 May 4;35(5):109088. doi: 10.1016/j.celrep.2021.109088. Cell Rep. 2021. PMID: 33951429 Free PMC article.

4

Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2.

Ladha FA, Thakar K, Pettinato AM, Legere N, Ghahremani S, Cohn R, Romano R, Meredith E, Chen YS, Hinson JT. Ladha FA, et al. Among authors: cohn r. Cell Rep. 2021 Aug 10;36(6):109512. doi: 10.1016/j.celrep.2021.109512. Cell Rep. 2021. PMID: 34380038 Free PMC article.

5

Adult mouse fibroblasts retain organ-specific transcriptomic identity.

Forte E, Ramialison M, Nim HT, Mara M, Li JY, Cohn R, Daigle SL, Boyd S, Stanley EG, Elefanty AG, Hinson JT, Costa MW, Rosenthal NA, Furtado MB. Forte E, et al. Among authors: cohn r. Elife. 2022 Mar 16;11:e71008. doi: 10.7554/eLife.71008. Elife. 2022. PMID: 35293863 Free PMC article.

6

Targeting p21^Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity.

Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Prata LGPL, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kshitiz, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M. Wang L, et al. Among authors: cohn rl. Cell Metab. 2022 Jan 4;34(1):75-89.e8. doi: 10.1016/j.cmet.2021.11.002. Epub 2021 Nov 22. Cell Metab. 2022. PMID: 34813734 Free PMC article.

7

Targeting p21^Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity.

Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Langhi Prata LGP, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kshitiz, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M. Wang L, et al. Among authors: cohn rl. Cell Metab. 2022 Jan 4;34(1):186. doi: 10.1016/j.cmet.2021.12.014. Cell Metab. 2022. PMID: 34986334 Free PMC article. No abstract available.

8

The heterogeneity of cellular senescence: insights at the single-cell level.

Cohn RL, Gasek NS, Kuchel GA, Xu M. Cohn RL, et al. Trends Cell Biol. 2023 Jan;33(1):9-17. doi: 10.1016/j.tcb.2022.04.011. Epub 2022 May 20. Trends Cell Biol. 2023. PMID: 35599179 Free PMC article. Review.

9

Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function.

Wang B, Wang L, Gasek NS, Kuo CL, Nie J, Kim T, Yan P, Zhu J, Torrance BL, Zhou Y, Flores LC, Allen C, Andrade AM, Guo C, Cohn RL, Jellison ER, Bartley JM, Kuchel GA, Li S, Pirtskhalava T, Tchkonia T, Yadav S, Haynes L, Kirkland JL, Ikeno Y, Xu M. Wang B, et al. Among authors: cohn rl. Cell Metab. 2024 Aug 6;36(8):1795-1805.e6. doi: 10.1016/j.cmet.2024.07.006. Cell Metab. 2024. PMID: 39111286 Free PMC article.

10

Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function.

Asadollahi R, Ahmad A, Boonsawat P, Shahanoor Hinzen J, Lohse M, Bouazza-Arostegui B, Sun S, Utesch T, Sommer JD, Ilic D, Padmanarayana M, Fischermanns K, Ranjan M, Boll M, Ka C, Piton A, Mattioli F, Isidor B, Õunap K, Reinson K, Wojcik MH, Marshall CR, Mercimek-Andrews S, Matsumoto N, Miyake N, Stephan BO, Honjo RS, Bertola DR, Kim CA, Yusupov R, Mefford HC, Christodoulou J, Lee J, Heath O, Brown NJ, Baker N, Stark Z, Delatycki M, Lake NJ, Zeidler S, Zuurbier L, Maas SM, de Kruiff CC, Rajabi F, Rodan LH, Coury SA, Platzer K, Oppermann H, Abou Jamra R, Beblo S, Maxton C, Śmigiel R, Underhill H, Dubbs H, Rosen A, Helbig KL, Helbig I, Ruggiero SM, Fitzgerald MP, Kraemer D, Prada CE, Tenney J, Jayakar P, Redon S, Lefranc J, Uguen K, Race S, Efthymiou S, Maroofian R, Houlden H, Coppens S, Deconinck N, Ashokkumar B, Varalakshmi P, Gowda K VR, Eghbal F, Ghayoor Karimiani E, Heidari M, Neidhardt J, Owczarek-Lipska M, Korenke GC, Bamshad MJ, Campeau PM, Lehman A, Hendon LG, Wentzensen IM, Monaghan KG, Chen Y, Szuto A, Cohn RD, Au PYB, Hübner C, Boschann F, Manickam K, Koboldt DC, Rad A, Oprea G, Bachman KK, Seeley AH, Agolini E, Terracciano A, Carmelo P, Bupp C, Grysko B, Rein-Roth… See abstract for full author list ➔ Asadollahi R, et al. Among authors: cohn rd. Nat Genet. 2025 Oct 22. doi: 10.1038/s41588-025-02361-5. Online ahead of print. Nat Genet. 2025. PMID: 41125872

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