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AICAr suppresses cell proliferation by inducing NTP and dNTP pool imbalances in acute lymphoblastic leukemia cells.
Du L, Yang F, Fang H, Sun H, Chen Y, Xu Y, Li H, Zheng L, Zhou BS. Du L, et al. Among authors: chen y. FASEB J. 2019 Mar;33(3):4525-4537. doi: 10.1096/fj.201801559RR. Epub 2019 Jan 31. FASEB J. 2019. PMID: 30702927
Our data indicate that RNA transcription inhibition and DNA replication stress induced by NTP and dNTP pool imbalances might play a key role in AICAr-mediated cytotoxic effects on ALL cells, suggesting a potential clinical application of AICAr in future ALL therapy.-Du, L., Yang, …
Our data indicate that RNA transcription inhibition and DNA replication stress induced by NTP and dNTP pool imbalances might play a key role …
Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.
Li B, Li H, Bai Y, Kirschner-Schwabe R, Yang JJ, Chen Y, Lu G, Tzoneva G, Ma X, Wu T, Li W, Lu H, Ding L, Liang H, Huang X, Yang M, Jin L, Kang H, Chen S, Du A, Shen S, Ding J, Chen H, Chen J, von Stackelberg A, Gu L, Zhang J, Ferrando A, Tang J, Wang S, Zhou BB. Li B, et al. Among authors: chen j, chen s, chen h, chen y. Nat Med. 2015 Jun;21(6):563-71. doi: 10.1038/nm.3840. Epub 2015 May 11. Nat Med. 2015. PMID: 25962120 Free PMC article.
Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse.
Yang F, Brady SW, Tang C, Sun H, Du L, Barz MJ, Ma X, Chen Y, Fang H, Li X, Kolekar P, Pathak O, Cai J, Ding L, Wang T, von Stackelberg A, Shen S, Eckert C, Klco JM, Chen H, Duan C, Liu Y, Li H, Li B, Kirschner-Schwabe R, Zhang J, Zhou BS. Yang F, et al. Among authors: chen h, chen y. Nat Cancer. 2021 Aug;2(8):819-834. doi: 10.1038/s43018-021-00230-8. Epub 2021 Jul 22. Nat Cancer. 2021. PMID: 35122027
Antileukemic effects of topoisomerase I inhibitors mediated by de-SUMOylase SENP1.
Niu Q, Hou W, Yan Y, Sun S, Lin Y, Fang H, Ma C, Dong C, Cheng Y, Xu Y, Ding M, Wang S, Cui Z, Chen Y, Li H, Li H, Xiao N. Niu Q, et al. Among authors: chen y. Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1;1868(12):166492. doi: 10.1016/j.bbadis.2022.166492. Epub 2022 Jul 16. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35850175 Free article.
198,911 results
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