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Page 1
Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.
Logtenberg MEW, Jansen JHM, Raaben M, Toebes M, Franke K, Brandsma AM, Matlung HL, Fauster A, Gomez-Eerland R, Bakker NAM, van der Schot S, Marijt KA, Verdoes M, Haanen JBAG, van den Berg JH, Neefjes J, van den Berg TK, Brummelkamp TR, Leusen JHW, Scheeren FA, Schumacher TN. Logtenberg MEW, et al. Among authors: verdoes m. Nat Med. 2019 Apr;25(4):612-619. doi: 10.1038/s41591-019-0356-z. Epub 2019 Mar 4. Nat Med. 2019. PMID: 30833751 Free PMC article.
Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering.
van der Schoot JMS, Fennemann FL, Valente M, Dolen Y, Hagemans IM, Becker AMD, Le Gall CM, van Dalen D, Cevirgel A, van Bruggen JAC, Engelfriet M, Caval T, Bentlage AEH, Fransen MF, Nederend M, Leusen JHW, Heck AJR, Vidarsson G, Figdor CG, Verdoes M, Scheeren FA. van der Schoot JMS, et al. Among authors: verdoes m. Sci Adv. 2019 Aug 28;5(8):eaaw1822. doi: 10.1126/sciadv.aaw1822. eCollection 2019 Aug. Sci Adv. 2019. PMID: 31489367 Free PMC article.
Dual Site-Specific Chemoenzymatic Antibody Fragment Conjugation Using CRISPR-Based Hybridoma Engineering.
Le Gall CM, van der Schoot JMS, Ramos-Tomillero I, Khalily MP, van Dalen FJ, Wijfjes Z, Smeding L, van Dalen D, Cammarata A, Bonger KM, Figdor CG, Scheeren FA, Verdoes M. Le Gall CM, et al. Among authors: verdoes m. Bioconjug Chem. 2021 Feb 17;32(2):301-310. doi: 10.1021/acs.bioconjchem.0c00673. Epub 2021 Jan 21. Bioconjug Chem. 2021. PMID: 33476135 Free PMC article.
Correction to: Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents Iris.
Hagemans IM, Wierstra PJ, Steuten K, Molkenboer-Kuenen JDM, van Dalen D, Ter Beest M, van der Schoot JMS, Ilina O, Gotthardt M, Figdor CG, Scheeren FA, Heskamp S, Verdoes M. Hagemans IM, et al. Among authors: verdoes m. J Nanobiotechnology. 2022 May 14;20(1):229. doi: 10.1186/s12951-022-01306-y. J Nanobiotechnology. 2022. PMID: 35568872 Free PMC article. No abstract available.
Regulatory T Cell Depletion Using a CRISPR Fc-Optimized CD25 Antibody.
van Elsas MJ, van der Schoot JMS, Bartels A, Steuten K, van Dalen D, Wijfjes Z, Figdor CG, van Hall T, van der Burg SH, Verdoes M, Scheeren FA. van Elsas MJ, et al. Among authors: verdoes m. Int J Mol Sci. 2022 Aug 5;23(15):8707. doi: 10.3390/ijms23158707. Int J Mol Sci. 2022. PMID: 35955841 Free PMC article.
PD-L1 checkpoint blockade promotes regulatory T cell activity that underlies therapy resistance.
van Gulijk M, van Krimpen A, Schetters S, Eterman M, van Elsas M, Mankor J, Klaase L, de Bruijn M, van Nimwegen M, van Tienhoven T, van Ijcken W, Boon L, van der Schoot J, Verdoes M, Scheeren F, van der Burg SH, Lambrecht BN, Stadhouders R, Dammeijer F, Aerts J, van Hall T. van Gulijk M, et al. Among authors: verdoes m. Sci Immunol. 2023 May 19;8(83):eabn6173. doi: 10.1126/sciimmunol.abn6173. Epub 2023 May 19. Sci Immunol. 2023. PMID: 37205768
Development of a Versatile Cancer Vaccine Format Targeting Antigen-Presenting Cells Using Proximity-Based Sortase A-Mediated Ligation of T-Cell Epitopes.
Wang AZ, Brink HJ, Bouma RG, Affandi AJ, Nijen Twilhaar MK, Heijnen DAM, van Elk J, Maaskant JJ, Konijn VAL, Stolwijk JGC, Kalay H, Olesek K, van Kooyk Y, van der Schoot JMS, Bentlage AEH, Scheeren FA, Verdoes M, Vidarsson G, Kuijl CP, den Haan JMM. Wang AZ, et al. Among authors: verdoes m. Bioconjug Chem. 2024 Nov 20;35(11):1805-1814. doi: 10.1021/acs.bioconjchem.4c00403. Epub 2024 Nov 7. Bioconjug Chem. 2024. PMID: 39511711 Free PMC article.
Site-directed multivalent conjugation of antibodies to ubiquitinated payloads.
El Hebieshy AF, Wijfjes Z, Le Gall CM, Middelburg J, de Roode KE, Fennemann FL, Sluijter M, van Hall T, Dijkstra DJ, Trouw LA, van Dalen FJ, Rodgers Furones A, van der Schoot JMS, Derksen I, de Haard H, van der Woning B, Talavera Ormeño CMP, van Doodewaerd BR, Figdor CG, van der Heden van Noort GJ, Parren PWHI, Heskamp S, Ovaa H, Verdoes M, Scheeren FA. El Hebieshy AF, et al. Among authors: verdoes m. Nat Biomed Eng. 2025 Jul;9(7):1101-1116. doi: 10.1038/s41551-024-01342-z. Epub 2025 Apr 9. Nat Biomed Eng. 2025. PMID: 40204992 Free PMC article.
101 results