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Page 1
CRISPR-Cas12-based detection of SARS-CoV-2.
Broughton JP, Deng X, Yu G, Fasching CL, Servellita V, Singh J, Miao X, Streithorst JA, Granados A, Sotomayor-Gonzalez A, Zorn K, Gopez A, Hsu E, Gu W, Miller S, Pan CY, Guevara H, Wadford DA, Chen JS, Chiu CY. Broughton JP, et al. Nat Biotechnol. 2020 Jul;38(7):870-874. doi: 10.1038/s41587-020-0513-4. Epub 2020 Apr 16. Nat Biotechnol. 2020. PMID: 32300245 Free PMC article.
COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 Enzyme.
Fasching CL, Servellita V, McKay B, Nagesh V, Broughton JP, Sotomayor-Gonzalez A, Wang B, Brazer N, Reyes K, Streithorst J, Deraney RN, Stanfield E, Hendriks CG, Fung B, Miller S, Ching J, Chen JS, Chiu CY. Fasching CL, et al. Among authors: broughton jp. J Clin Microbiol. 2022 Jul 20;60(7):e0026122. doi: 10.1128/jcm.00261-22. Epub 2022 Jun 29. J Clin Microbiol. 2022. PMID: 35766492 Free PMC article.
CRISPR-Cas enzymes: The toolkit revolutionizing diagnostics.
Verosloff MS, Shapiro SJ, Hawkins EM, Alpay E, Verma D, Stanfield EG, Kreindler L, Jain S, McKay B, Hubbell SA, Hendriks CG, Blizard BA, Broughton JP, Chen JS. Verosloff MS, et al. Among authors: broughton jp. Biotechnol J. 2022 Jul;17(7):e2100304. doi: 10.1002/biot.202100304. Epub 2021 Sep 23. Biotechnol J. 2022. PMID: 34505742
m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways.
Li HB, Tong J, Zhu S, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, Wang G, Broughton JP, Chen YG, Kluger Y, Simon MD, Chang HY, Yin Z, Flavell RA. Li HB, et al. Among authors: broughton jp. Nature. 2017 Aug 17;548(7667):338-342. doi: 10.1038/nature23450. Epub 2017 Aug 9. Nature. 2017. PMID: 28792938 Free PMC article.
m6A mRNA methylation sustains Treg suppressive functions.
Tong J, Cao G, Zhang T, Sefik E, Amezcua Vesely MC, Broughton JP, Zhu S, Li H, Li B, Chen L, Chang HY, Su B, Flavell RA, Li HB. Tong J, et al. Among authors: broughton jp. Cell Res. 2018 Feb;28(2):253-256. doi: 10.1038/cr.2018.7. Epub 2018 Jan 5. Cell Res. 2018. PMID: 29303144 Free PMC article. No abstract available.
N6-Methyladenosine Modification Controls Circular RNA Immunity.
Chen YG, Chen R, Ahmad S, Verma R, Kasturi SP, Amaya L, Broughton JP, Kim J, Cadena C, Pulendran B, Hur S, Chang HY. Chen YG, et al. Among authors: broughton jp. Mol Cell. 2019 Oct 3;76(1):96-109.e9. doi: 10.1016/j.molcel.2019.07.016. Epub 2019 Aug 29. Mol Cell. 2019. PMID: 31474572 Free PMC article.
Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation.
Carter AC, Xu J, Nakamoto MY, Wei Y, Zarnegar BJ, Shi Q, Broughton JP, Ransom RC, Salhotra A, Nagaraja SD, Li R, Dou DR, Yost KE, Cho SW, Mistry A, Longaker MT, Khavari PA, Batey RT, Wuttke DS, Chang HY. Carter AC, et al. Among authors: broughton jp. Elife. 2020 May 7;9:e54508. doi: 10.7554/eLife.54508. Elife. 2020. PMID: 32379046 Free PMC article.
RNA structure maps across mammalian cellular compartments.
Sun L, Fazal FM, Li P, Broughton JP, Lee B, Tang L, Huang W, Kool ET, Chang HY, Zhang QC. Sun L, et al. Among authors: broughton jp. Nat Struct Mol Biol. 2019 Apr;26(4):322-330. doi: 10.1038/s41594-019-0200-7. Epub 2019 Mar 18. Nat Struct Mol Biol. 2019. PMID: 30886404 Free PMC article.
16 results