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CRISPR-Cas12-based detection of SARS-CoV-2.
Broughton JP, Deng X, Yu G, Fasching CL, Servellita V, Singh J, Miao X, Streithorst JA, Granados A, Sotomayor-Gonzalez A, Zorn K, Gopez A, Hsu E, Gu W, Miller S, Pan CY, Guevara H, Wadford DA, Chen JS, Chiu CY. Broughton JP, et al. Among authors: chen js. Nat Biotechnol. 2020 Jul;38(7):870-874. doi: 10.1038/s41587-020-0513-4. Epub 2020 Apr 16. Nat Biotechnol. 2020. PMID: 32300245 Free PMC article.
Rapid Detection of 2019 Novel Coronavirus SARS-CoV-2 Using a CRISPR-based DETECTR Lateral Flow Assay.
Broughton JP, Deng X, Yu G, Fasching CL, Singh J, Streithorst J, Granados A, Sotomayor-Gonzalez A, Zorn K, Gopez A, Hsu E, Gu W, Miller S, Pan CY, Guevara H, Wadford DA, Chen JS, Chiu CY. Broughton JP, et al. Among authors: chen js. medRxiv [Preprint]. 2020 Mar 27:2020.03.06.20032334. doi: 10.1101/2020.03.06.20032334. medRxiv. 2020. PMID: 32511449 Free PMC article. Preprint.
CRISPR-Cas enzymes: The toolkit revolutionizing diagnostics.
Verosloff MS, Shapiro SJ, Hawkins EM, Alpay E, Verma D, Stanfield EG, Kreindler L, Jain S, McKay B, Hubbell SA, Hendriks CG, Blizard BA, Broughton JP, Chen JS. Verosloff MS, et al. Among authors: chen js. Biotechnol J. 2022 Jul;17(7):e2100304. doi: 10.1002/biot.202100304. Epub 2021 Sep 23. Biotechnol J. 2022. PMID: 34505742
COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 Enzyme.
Fasching CL, Servellita V, McKay B, Nagesh V, Broughton JP, Sotomayor-Gonzalez A, Wang B, Brazer N, Reyes K, Streithorst J, Deraney RN, Stanfield E, Hendriks CG, Fung B, Miller S, Ching J, Chen JS, Chiu CY. Fasching CL, et al. Among authors: chen js. J Clin Microbiol. 2022 Jul 20;60(7):e0026122. doi: 10.1128/jcm.00261-22. Epub 2022 Jun 29. J Clin Microbiol. 2022. PMID: 35766492 Free PMC article.
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
Chen JS, Dagdas YS, Kleinstiver BP, Welch MM, Sousa AA, Harrington LB, Sternberg SH, Joung JK, Yildiz A, Doudna JA. Chen JS, et al. Nature. 2017 Oct 19;550(7676):407-410. doi: 10.1038/nature24268. Epub 2017 Sep 20. Nature. 2017. PMID: 28931002 Free PMC article.
A scoutRNA Is Required for Some Type V CRISPR-Cas Systems.
Harrington LB, Ma E, Chen JS, Witte IP, Gertz D, Paez-Espino D, Al-Shayeb B, Kyrpides NC, Burstein D, Banfield JF, Doudna JA. Harrington LB, et al. Among authors: chen js. Mol Cell. 2020 Aug 6;79(3):416-424.e5. doi: 10.1016/j.molcel.2020.06.022. Epub 2020 Jul 8. Mol Cell. 2020. PMID: 32645367 Free PMC article.
CRISPR: fundamental principles and implications for anaesthesia.
Perez AR, Mavrothalassitis O, Chen JS, Hellman J, Gropper MA. Perez AR, et al. Among authors: chen js. Br J Anaesth. 2025 Mar;134(3):839-852. doi: 10.1016/j.bja.2024.11.040. Epub 2025 Jan 23. Br J Anaesth. 2025. PMID: 39855935 Free PMC article. Review.
3,230 results