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The novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long-acting GLP-1 receptor agonists.
Urva S, Coskun T, Loghin C, Cui X, Beebe E, O'Farrell L, Briere DA, Benson C, Nauck MA, Haupt A. Urva S, et al. Among authors: beebe e. Diabetes Obes Metab. 2020 Oct;22(10):1886-1891. doi: 10.1111/dom.14110. Epub 2020 Jul 13. Diabetes Obes Metab. 2020. PMID: 32519795 Free PMC article.
Development of a long-acting relaxin analogue, LY3540378, for treatment of chronic heart failure.
Verdino P, Lee SL, Cooper FN, Cottle SR, Grealish PF, Hu CC, Meyer CM, Lin J, Copeland V, Porter G, Schroeder RL, Thompson TD, Porras LL, Dey A, Zhang HY, Beebe EC, Matkovich SJ, Coskun T, Balciunas AM, Ferrante A, Siegel R, Malherbe L, Bivi N, Paavola CD, Hansen RJ, Abernathy MM, Nwosu SO, Carr MC, Heuer JG, Wang X. Verdino P, et al. Br J Pharmacol. 2023 Aug;180(15):1965-1980. doi: 10.1111/bph.16055. Epub 2023 Mar 8. Br J Pharmacol. 2023. PMID: 36780899 Free article.
Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor.
Regmi A, Aihara E, Christe ME, Varga G, Beyer TP, Ruan X, Beebe E, O'Farrell LS, Bellinger MA, Austin AK, Lin Y, Hu H, Konkol DL, Wojnicki S, Holland AK, Friedrich JL, Brown RA, Estelle AS, Badger HS, Gaidosh GS, Kooijman S, Rensen PCN, Coskun T, Thomas MK, Roell W. Regmi A, et al. Among authors: beebe e. Cell Metab. 2024 Jul 2;36(7):1534-1549.e7. doi: 10.1016/j.cmet.2024.05.010. Epub 2024 Jun 14. Cell Metab. 2024. PMID: 38878772 Free article.
Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor.
Regmi A, Aihara E, Christe ME, Varga G, Beyer TP, Ruan X, Beebe E, O'Farrell LS, Bellinger MA, Austin AK, Lin Y, Hu H, Konkol DL, Wojnicki S, Holland AK, Friedrich JL, Brown RA, Estelle AS, Badger HS, Gaidosh GS, Kooijman S, Rensen PCN, Coskun T, Thomas MK, Roell W. Regmi A, et al. Among authors: beebe e. Cell Metab. 2024 Aug 6;36(8):1898-1899. doi: 10.1016/j.cmet.2024.06.012. Epub 2024 Jun 29. Cell Metab. 2024. PMID: 38945123 Free article. No abstract available.
Illustrating an Adaptive Prespecification Framework for Observational Research: Target Trial Emulations Comparing Immunomodulator Treatments for COVID-19.
Weckstein AR, Frajzyngier V, Vititoe SE, Baglivo A, Beebe E, Govil P, Bradley MC, Perez-Vilar S, Liu W, Rivera DR, Lasky T, Chakravarty A, Garry EM, Gatto NM. Weckstein AR, et al. Among authors: beebe e. Epidemiology. 2025 Nov 1;36(6):791-801. doi: 10.1097/EDE.0000000000001901. Epub 2025 Aug 20. Epidemiology. 2025. PMID: 40996066 Free PMC article.
Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs of type 1 diabetes progression.
Melton R, Jimenez S, Elison W, Tucciarone L, Howell A, Wang G, Berti D, Beebe E, Miller M, Zeng C, McGrail C, VanderStel K, Korgaonkar K, Elgamal R, Mummey H, Chiou J, Griffin E, Kusmartseva I, Atkinson M, Preissl S, Theis FJ, Sander M, Gaulton KJ. Melton R, et al. Among authors: beebe e. Sci Adv. 2025 Sep 12;11(37):eady0080. doi: 10.1126/sciadv.ady0080. Epub 2025 Sep 10. Sci Adv. 2025. PMID: 40929272 Free PMC article.
Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression.
Melton R, Jimenez S, Elison W, Tucciarone L, Howell A, Wang G, Berti D, Beebe E, Miller M, Zeng C, McGrail C, VanderStel K, Korgaonkar K, Elgamal R, Mummey H, Chiou J, Griffin E, Kusmartseva I, Atkinson M, Preissl S, Theis FJ, Sander M, Gaulton KJ. Melton R, et al. Among authors: beebe e. bioRxiv [Preprint]. 2025 Mar 17:2025.02.13.637721. doi: 10.1101/2025.02.13.637721. bioRxiv. 2025. Update in: Sci Adv. 2025 Sep 12;11(37):eady0080. doi: 10.1126/sciadv.ady0080. PMID: 40027657 Free PMC article. Updated. Preprint.
75 results