Springsteen G - Search Results

1

The Messy Alkaline Formose Reaction and Its Link to Metabolism.

Omran A, Menor-Salvan C, Springsteen G, Pasek M. Omran A, et al. Among authors: springsteen g. Life (Basel). 2020 Jul 28;10(8):125. doi: 10.3390/life10080125. Life (Basel). 2020. PMID: 32731352 Free PMC article.

2

From Amino Acids to α-Keto Acids via β-Elimination and Transamination Initiates a Pathway to Prebiotic Reaction Networks.

Ter-Ovanessian LMP, Ryan KL, Shaarda J, Stubbs RT, Krishnamurthy R, Springsteen G. Ter-Ovanessian LMP, et al. Among authors: springsteen g. Angew Chem Int Ed Engl. 2025 Jul;64(29):e202507248. doi: 10.1002/anie.202507248. Epub 2025 Jun 2. Angew Chem Int Ed Engl. 2025. PMID: 40344525 Free PMC article.

3

Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle.

Springsteen G, Yerabolu JR, Nelson J, Rhea CJ, Krishnamurthy R. Springsteen G, et al. Nat Commun. 2018 Jan 8;9(1):91. doi: 10.1038/s41467-017-02591-0. Nat Commun. 2018. PMID: 29311556 Free PMC article.

4

A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids.

Stubbs RT, Yadav M, Krishnamurthy R, Springsteen G. Stubbs RT, et al. Among authors: springsteen g. Nat Chem. 2020 Nov;12(11):1016-1022. doi: 10.1038/s41557-020-00560-7. Epub 2020 Oct 12. Nat Chem. 2020. PMID: 33046840 Free PMC article.

5

A unified mechanism for abiotic adenine and purine synthesis in formamide.

Hudson JS, Eberle JF, Vachhani RH, Rogers LC, Wade JH, Krishnamurthy R, Springsteen G. Hudson JS, et al. Among authors: springsteen g. Angew Chem Int Ed Engl. 2012 May 21;51(21):5134-7. doi: 10.1002/anie.201108907. Epub 2012 Apr 5. Angew Chem Int Ed Engl. 2012. PMID: 22488748 No abstract available.

6

Synthesis of 2-Thioorotidine and Comparison of Its Unusual Instability with Its Canonical Pyrimidine Counterparts.

Kumar R, Springsteen G, Krishnamurthy R. Kumar R, et al. Among authors: springsteen g. J Org Chem. 2019 Nov 15;84(22):14427-14435. doi: 10.1021/acs.joc.9b01546. Epub 2019 Oct 28. J Org Chem. 2019. PMID: 31608636

7

A Plausible Prebiotic One-Pot Synthesis of Orotate and Pyruvate Suggestive of Common Protometabolic Pathways.

Clay AP, Cooke RE, Kumar R, Yadav M, Krishnamurthy R, Springsteen G. Clay AP, et al. Among authors: springsteen g. Angew Chem Int Ed Engl. 2022 Mar 7;61(11):e202112572. doi: 10.1002/anie.202112572. Epub 2022 Jan 27. Angew Chem Int Ed Engl. 2022. PMID: 35007387 Free PMC article.

8

Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways.

Pulletikurti S, Yadav M, Springsteen G, Krishnamurthy R. Pulletikurti S, et al. Among authors: springsteen g. Nat Chem. 2022 Oct;14(10):1142-1150. doi: 10.1038/s41557-022-00999-w. Epub 2022 Jul 28. Nat Chem. 2022. PMID: 35902742

9

Conversion of a ribozyme to a deoxyribozyme through in vitro evolution.

Paul N, Springsteen G, Joyce GF. Paul N, et al. Among authors: springsteen g. Chem Biol. 2006 Mar;13(3):329-38. doi: 10.1016/j.chembiol.2006.01.007. Chem Biol. 2006. PMID: 16638538

10

Reaching Back to Jump Forward: Recent Efforts towards a Systems-Level Hypothesis for an Early RNA World.

Springsteen G. Springsteen G. Chembiochem. 2015 Jul 6;16(10):1411-3. doi: 10.1002/cbic.201500233. Epub 2015 Jun 1. Chembiochem. 2015. PMID: 26010529

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